{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:26:12Z","timestamp":1791559572951,"version":"4.3.4"},"reference-count":88,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,10,10]],"date-time":"2013-10-10T00:00:00Z","timestamp":1381363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern J of Cosmetic Sci"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Synopsis<\/jats:title>\n                  <jats:p>\n                    An obvious sign of ageing is hair greying, or the loss of pigment production and deposition within the hair shafts. Numerous mechanisms, acting at different levels and follicular locations, contribute to hair greying, ranging from melanocyte stem cells defects to follicular melanocyte death. One key issue that is in common to these processes is oxidative damage. At the hair follicle stem cells niche, oxidative stress, accelerated by B\u2010cell lymphoma 2 gene (\n                    <jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>\n                    \u20102) depletion, leads to selective apoptosis and diminution of melanocyte stem cells, reducing the repopulation of newly formed anagen follicles. Melanotic bulbar melanocytes express high levels of\n                    <jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>\n                    \u20102 to enable survival from melanogenesis\u2010 and ultraviolet A (\n                    <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>\n                    )\u2010induced reactive oxygen species (\n                    <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>\n                    ) attacks. With ageing, the bulbar melanocyte expression of anti\u2010oxidant proteins such as\n                    <jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>\n                    \u20102, and possibly\n                    <jats:styled-content style=\"fixed-case\">TRP<\/jats:styled-content>\n                    \u20102, is reduced, and the dedicated enzymatic anti\u2010oxidant defence system throughout the follicle weakens, resulting in enhanced oxidative stress. A marked reduction in catalase expression and activity results in millimolar accumulation of hydrogen peroxide, contributing to bulbar melanocyte malfunction and death. Interestingly, amelanotic melanocytes at the outer root sheath (\n                    <jats:styled-content style=\"fixed-case\">ORS<\/jats:styled-content>\n                    ) are somewhat less affected by these processes and survive for longer time even within the white, ageing hair follicles. Better understanding of the overtime susceptibility of melanocytes to oxidative stress at the different follicular locations might yield clues to possible therapies for the prevention and reversal of hair greying.\n                  <\/jats:p>","DOI":"10.1111\/ics.12090","type":"journal-article","created":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T10:25:05Z","timestamp":1377685505000},"page":"532-538","source":"Crossref","is-referenced-by-count":83,"title":["Age\u2010induced hair greying \u2013 the multiple effects of oxidative stress"],"prefix":"10.1111","volume":"35","author":[{"given":"M.","family":"Seiberg","sequence":"first","affiliation":[{"name":"Seiberg Consulting LLC Princeton NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,10]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11095.x"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2009.05.022"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.03.028"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/276627a0"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.1993.tb00600.x"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(85)91288-4"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(86)90149-2"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx980114c"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.1993.tb00612.x"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11624"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(00)00157-8"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.cmr.0000195699.35143.df"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000157007"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2001.140303.x"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00653.x"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1951.tb31954.x"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00417.x"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12460956"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2000.130407.x"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2011.00855.x"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.883475"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-012-0943-3"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2010.11.029"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11847"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.05.004"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2001.140402.x"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2007.04.001"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7753.58550"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(00)00210-2"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micron.2003.11.006"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2008.00456.x"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/207877a0"},{"key":"e_1_2_13_34_1","first-page":"29","article-title":"Optical properties of hair\u2013detailed examination of specular reflection patterns in various hair types","volume":"55","author":"McMullen R.","year":"2004","journal-title":"J. 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