{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T16:55:35Z","timestamp":1769014535689,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,9]],"date-time":"2013-11-09T00:00:00Z","timestamp":1383955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern J of Cosmetic Sci"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Synopsis<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p><jats:italic>Malassezia<\/jats:italic> species are frequently associated with dandruff and seborrhoeic dermatitis. The study was conducted to evaluate anti\u2010fungal activities of the extracts obtained from the roots of <jats:italic>Asparagus racemosus<\/jats:italic> Willd against <jats:italic>Malassezia furfur<\/jats:italic> and <jats:italic>M.\u00a0globosa<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>Asparagus racemosus<\/jats:italic> roots were successively extracted with the series of solvents, that is, hexane, ethanol and water, and also a saponin\u2010enriched fraction was prepared. The amounts of saponin (equivalent to shatavarin IV) in the extracts were determined using ELISA. The extracts were tested for anti\u2010fungal activity by disc diffusion and broth microdilution methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>By disc diffusion, only the ethanolic and saponin\u2010enriched extracts demonstrated anti\u2010fungal activity against <jats:italic>M.\u00a0furfur<\/jats:italic> and <jats:italic>M.\u00a0globosa<\/jats:italic> at the concentration of 1\u00a0mg per disc whereas the extracts with other solvents were ineffective. Multiple concentrations using the broth microdilution method against <jats:italic>M.\u00a0furfur<\/jats:italic> and <jats:italic>M.\u00a0globosa<\/jats:italic> yielded minimum inhibitory concentrations (MICs) of 25\u00a0mg\u00a0mL<jats:sup>\u22121<\/jats:sup> for the ethanolic extract but much higher potency for the saponin\u2010enriched extract: MICs to 0.20 and 0.40\u00a0mg\u00a0mL<jats:sup>\u22121<\/jats:sup> for <jats:italic>M.\u00a0furfur<\/jats:italic> and <jats:italic>M.\u00a0globosa<\/jats:italic>, respectively. These extracts showed no antagonist effect with the anti\u2010fungal agents, ketoconazole and zinc pyrithione.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These studies revealed the antifungal activity of A. racemosus roots extracts. Because <jats:italic>A.\u00a0racemosus<\/jats:italic> is also anti\u2010inflammatory agent, it has the potential use as an active ingredient in an anti\u2010dandruff formulation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ics.12098","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:28:07Z","timestamp":1381544887000},"page":"74-78","source":"Crossref","is-referenced-by-count":30,"title":["<i>In vitro<\/i> anti\u2010<i>Malassezia<\/i> activity and potential use in anti\u2010dandruff formulation of <i>Asparagus racemosus<\/i>"],"prefix":"10.1111","volume":"36","author":[{"given":"C.","family":"Onlom","sequence":"first","affiliation":[{"name":"Bioscreening Unit Department of Pharmaceutical Chemistry and Pharmacognosy Faculty of Pharmaceutical Sciences Center of Excellence for Innovation in Chemistry Naresuan University Phitsanulok 65000 Thailand"},{"name":"Cosmetic and Natural Product Research Unit Faculty of Pharmaceutical Sciences Naresuan University Phitsanulok 65000 Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Khanthawong","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology Faculty of Medical Sciences Naresuan University Phitsanulok 65000 Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Waranuch","sequence":"additional","affiliation":[{"name":"Cosmetic and Natural Product Research Unit Faculty of Pharmaceutical Sciences Naresuan University Phitsanulok 65000 Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Ingkaninan","sequence":"additional","affiliation":[{"name":"Bioscreening Unit Department of Pharmaceutical Chemistry and Pharmacognosy Faculty of Pharmaceutical Sciences Center of Excellence for Innovation in Chemistry Naresuan University Phitsanulok 65000 Thailand"},{"name":"Cosmetic and Natural Product Research Unit Faculty of Pharmaceutical Sciences Naresuan University Phitsanulok 65000 Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.12.034"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007132830164"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2010.03.021"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.05.048"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2006.10.008"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398709527461"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(99)00212-9"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb1961.54.2553"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(88)80186-9"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2007.02.005"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2007.02.033"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2006.10.009"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.05.016"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.01.001"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1590"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1573(200003)14:2<118::AID-PTR493>3.0.CO;2-P"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/0250-474X.56017"},{"key":"e_1_2_6_19_1","first-page":"39","article-title":"Anti\u2010diarrhoeal potential of Asparagus racemosus wild root extracts in laboratory animals","volume":"8","author":"Venkatesan N.","year":"2005","journal-title":"J. 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