{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:53:17Z","timestamp":1790679197558,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T00:00:00Z","timestamp":1393200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern J of Cosmetic Sci"],"published-print":{"date-parts":[[2014,6]]},"abstract":"Synopsis<\/jats:title>\n \n Objective<\/jats:title>\n To evaluate wrinkle improvement and safety of a novel cosmetic dissolving microneedle patches loaded with two active compounds with different hydrophilicities, namely ascorbic acid and retinyl retinoate.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Clinical studies were performed on 24\n K<\/jats:styled-content>\n orean women for 12\u00a0weeks. Patients in group\n A<\/jats:styled-content>\n were treated with retinyl retinoate\u2010loaded dissolving microneedle patches on the left eye crow's feet area, and patients in group\n B<\/jats:styled-content>\n were treated with ascorbic acid\u2010loaded patches on the right eye crow's feet area twice daily. Wrinkle improvement was evaluated by skin\n V<\/jats:styled-content>\n isiometer\n SV<\/jats:styled-content>\n 600.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Both the retinyl retinoate\u2010 and ascorbic acid\u2010loaded dissolving microneedle patches demonstrated statistically significant differences in all\n V<\/jats:styled-content>\n isiometer\n \n R<\/jats:styled-content>\n <\/jats:italic>\n \u2010values (\n P<\/jats:italic>\n \u00a0<\u00a00.05). In particular, highly significant differences were shown at\n \n R<\/jats:styled-content>\n <\/jats:italic>\n 1 (skin roughness) and\n \n R<\/jats:styled-content>\n <\/jats:italic>\n 5 (arithmetic average roughness) (\n P<\/jats:italic>\n \u00a0<\u00a00.001). Also, there were no side effects such as allergies or irritant contact dermatitis.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Retinyl retinoate and ascorbic acid were successfully loaded into dissolving microneedles and used to produce novel cosmetic patches. These novel patches can be used efficiently in cosmetics given their patient usability, safety and effectiveness in wrinkle improvement.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ics.12115","type":"journal-article","created":{"date-parts":[[2014,1,19]],"date-time":"2014-01-19T04:50:52Z","timestamp":1390107052000},"page":"207-212","source":"Crossref","is-referenced-by-count":118,"title":["Novel cosmetic patches for wrinkle improvement: retinyl retinoate\u2010 and ascorbic acid\u2010loaded dissolving microneedles"],"prefix":"10.1111","volume":"36","author":[{"given":"M.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Biotechnology Yonsei University Shinchon\u2010dong Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Yonsei University Shinchon\u2010dong Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Foundation of Korea Cosmetic Industry Institute Osan\u2010si Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Clinical Evaluation Ellead Skin Evaluation Center Seohyun\u2010dong Seongnam\u2010si Kyunggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Yonsei University Shinchon\u2010dong Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000211136"},{"key":"e_1_2_6_3_1","first-page":"1145","article-title":"Modern approach to topical treatment of aging skin","volume":"34","author":"Puizina\u2010Ivic N.","year":"2010","journal-title":"Coll. 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