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Furthermore, there is a need to improve the topical treatment for nail diseases to avoid drug interactions and to reduce side effects associated with oral therapy. Topical drug delivery to the nails has established amplified consideration lately. Strategies (such as chemical enhancers, formulation strategies, physical and mechanical methods) are being investigated in order to improve drug permeability across the nail plate. The rationale of this review is to present contemporary information on the structure of human nail along with its comparison with animal hooves. Precincts of nail permeability have been briefly discussed with respect to factors like permeant's molecular size, hydrophilicity, charge and the nature of the vehicle. These factors affect drug uptake and permeation through the nail. Formulations like nail lacquers which mimic cosmetic varnish and colloidal carriers along with nail substitutes that can be utilized for transungual delivery have also been discussed.<\/jats:p>","DOI":"10.1111\/ics.12142","type":"journal-article","created":{"date-parts":[[2014,5,29]],"date-time":"2014-05-29T04:43:14Z","timestamp":1401338594000},"page":"398-411","source":"Crossref","is-referenced-by-count":34,"title":["Transungual delivery: deliberations and creeds"],"prefix":"10.1111","volume":"36","author":[{"given":"P.","family":"Thatai","sequence":"first","affiliation":[{"name":"Pharmaceutics Division Department of Pharmaceutical Sciences Punjabi University Patiala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Sapra","sequence":"additional","affiliation":[{"name":"Pharmaceutics Division Department of Pharmaceutical Sciences Punjabi University Patiala India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2494.2007.00372.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.149.s65.2.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2011.01.022"},{"key":"e_1_2_9_5_1","first-page":"1","volume-title":"Topical Nail Products and Ungual Drug Delivery","author":"Murdan S.","year":"2013"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21025"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03246.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1211\/0022357991772448"},{"key":"e_1_2_9_9_1","first-page":"101","article-title":"Nail drug delivery system: a review","volume":"2","author":"Pati N.B.","year":"2012","journal-title":"J. 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