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Endpoints measured included expert grades of skin condition, stratum corneum (<jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>) hydration, <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> barrier function, elasticity and surface topography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">GSS<\/jats:styled-content> complex produced significant single\u2010variable (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05) improvements in <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> hydration, barrier function, elasticity and surface topography compared with the Vehicle control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">GSS<\/jats:styled-content> complex examined in this study represents an interesting new cosmetic topical technology with which to address multiple aspects of aged\/photoaged female facial skin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ics.12237","type":"journal-article","created":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T07:49:04Z","timestamp":1430725744000},"page":"606-612","source":"Crossref","is-referenced-by-count":16,"title":["Randomized, double\u2010blinded, vehicle\u2010controlled, split\u2010face study to evaluate the effects of topical application of a Gold Silk Sericin\/Niacinamide\/Signaline complex on biophysical parameters related to skin ageing"],"prefix":"10.1111","volume":"37","author":[{"given":"E.","family":"Berardesca","sequence":"first","affiliation":[{"name":"San Gallicano Dermatological Institute Via Chianesi 53 00144 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ardigo","sequence":"additional","affiliation":[{"name":"San Gallicano Dermatological Institute Via Chianesi 53 00144 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Cameli","sequence":"additional","affiliation":[{"name":"Department of Clinical Dermatology San Gallicano Institute Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mariano","sequence":"additional","affiliation":[{"name":"San Gallicano Dermatological Institute Via Chianesi 53 00144 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Agozzino","sequence":"additional","affiliation":[{"name":"San Gallicano Dermatological Institute Via Chianesi 53 00144 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.J.","family":"Matts","sequence":"additional","affiliation":[{"name":"Procter &amp; Gamble London Innovation Centre Egham Surrey TW20 9NW U.K"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02505041"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.19636.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1987.9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12371763"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041510119"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000247727"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0734-9750(02)00003-4"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.04.067"},{"key":"e_1_2_6_10_1","first-page":"141","article-title":"Physiological genetics of the carotenoids in Bombyx mori, with special reference to the pink cocoon","volume":"14","author":"Harizuka M.","year":"1953","journal-title":"Bull Seric. 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