{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T07:14:26Z","timestamp":1784099666491,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T00:00:00Z","timestamp":1505952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern J of Cosmetic Sci"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate a combination of retinyl propionate and climbazole (<jats:styled-content style=\"fixed-case\">RPC<\/jats:styled-content>) compared to 0.1% retinol for its efficacy, tolerance and ageing appearance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Forty\u2010five healthy Caucasian females, ages 40\u201370, with moderately photodamaged facial skin, were recruited for a 16\u2010week randomized, double\u2010blind,<jats:styled-content style=\"fixed-case\">IRB<\/jats:styled-content>\u2010approved facial study. The efficacy of<jats:styled-content style=\"fixed-case\">RPC<\/jats:styled-content>treatment was compared to 0.1% retinol, in the same product base formulation, with twice daily, split\u2010face product application. Changes in overall photodamage, fine lines and wrinkles, pigmentation and irritation were visually evaluated and measured by instrumentation. Subjective appraisal of efficacy was self\u2010assessed from images where subjects were blinded to treatment and time point. Irritancy potential was also evaluated in a 5\u2010day randomized, double\u2010blind,<jats:styled-content style=\"fixed-case\">IRB<\/jats:styled-content>\u2010approved patch study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment with<jats:styled-content style=\"fixed-case\">RPC<\/jats:styled-content>resulted in significant (<jats:italic>P<\/jats:italic>&lt; 0.05) improvement in ageing attributes compared to 0.1% retinol treatment, with minimal irritation. More than 50% of subjects showed improvement to deep wrinkles in the crow's feet area after 5 weeks of product application, and continued improvement to deep wrinkles was observed throughout the course of the study. Similarly, improvement was observed for the appearance of lines and wrinkles in the nasolabial fold (<jats:styled-content style=\"fixed-case\">NLF<\/jats:styled-content>) and for mottled hyperpigmentation. The results from subjective self\u2010assessment confirmed<jats:italic>in vivo<\/jats:italic>clinical assessments. In a separate patch study, significantly less irritation was observed with the<jats:styled-content style=\"fixed-case\">RPC<\/jats:styled-content>product as compared to the 0.1% retinol control product.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">RPC<\/jats:styled-content>delivered significant skin anti\u2010ageing benefits comparable or greater than 0.1% retinol, with minimal irritation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ics.12412","type":"journal-article","created":{"date-parts":[[2017,7,22]],"date-time":"2017-07-22T08:52:41Z","timestamp":1500713561000},"page":"589-599","source":"Crossref","is-referenced-by-count":8,"title":["Retinyl propionate and climbazole combination demonstrates clinical improvement to the appearance of hyperpigmentation and deep wrinkling with minimal irritation"],"prefix":"10.1111","volume":"39","author":[{"given":"S.","family":"Hawkins","sequence":"first","affiliation":[{"name":"Unilever Research and Development Trumbull CT 06611 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0621-7214","authenticated-orcid":false,"given":"J.","family":"Adamus","sequence":"additional","affiliation":[{"name":"Unilever Research and Development Trumbull CT 06611 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.\u2010y.","family":"Chiang","sequence":"additional","affiliation":[{"name":"Unilever Research and Development Trumbull CT 06611 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Covell","sequence":"additional","affiliation":[{"name":"Unilever Research and Development Trumbull CT 06611 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"O'Leary","sequence":"additional","affiliation":[{"name":"Unilever Research and Development Trumbull CT 06611 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010m.","family":"Lee","sequence":"additional","affiliation":[{"name":"Unilever Research and Development Trumbull CT 06611 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(20)30065-X"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425250903032681"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12470632"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12323445"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00902.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12471816"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.1998.tb00339.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700202"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12342972"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1001\/archderm.1995.01690210067011","article-title":"Two concentrations of topical tretinoin (retinoic acid) cause similar improvement of photoaging but different degrees of irritation: a double\u2010blind, vehicle controlled comparison of 0.1% and 0.025% tretinoin creams","volume":"131","author":"Griffiths C.E.M.","year":"1995","journal-title":"Arch. 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