{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:57:34Z","timestamp":1786985854365,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T00:00:00Z","timestamp":1515110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31501415"],"award-info":[{"award-number":["31501415"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005706","name":"Beijing Technology and Business University","doi-asserted-by":"publisher","award":["19008001060"],"award-info":[{"award-number":["19008001060"]}],"id":[{"id":"10.13039\/501100005706","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intern J of Cosmetic Sci"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Sensitive skin (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>) is a condition characterised by high reactivity, low tolerance, and susceptibility to allergies of the skin. Owing to changes in the environment and marketing strategies, as well as the increasing public awareness about skin care, attention to skin condition is gradually increasing. The aim of this study is to explore the differences in the skin barrier of <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> and normal skin (<jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A questionnaire survey was conducted and basic indicators of the skin barrier were analysed. It was found that sebum secretion in the <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> group was lower than that in the <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content> group, suggesting that the development of <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> might be associated with sebum secretion and its specific components. Next, an ultra performance liquid chromatography\u2010quadruple time\u2010of\u2010flight mass spectrometer was used to identify facial sebum components in female volunteers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results showed that the sebum of female volunteers with <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> had high levels of ceramides, glycerophosphoethanolamines, and diacylglycerols, and low levels of glucosylceramides, glycerophosphoserines, glycerophosphocholines, and triacylglycerols.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Analysis of lipid functions suggested that the main reason for <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> development in women might be a barrier dysfunction caused by excessive apoptosis and lack of water. Therefore, anti\u2010allergy additives in cosmetic products that could inhibit apoptosis of keratinocytes and methods to maintain the stability of water molecules in the skin should be further studied.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ics.12442","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T14:46:27Z","timestamp":1512657987000},"page":"117-126","source":"Crossref","is-referenced-by-count":43,"title":["Analysis of sensitive skin barrier function: basic indicators and sebum composition"],"prefix":"10.1111","volume":"40","author":[{"given":"L.","family":"Fan","sequence":"first","affiliation":[{"name":"School of Science\/Key Laboratory of Cosmetic China National Light Industry Beijing Technology and Business University Beijing 100048 China"},{"name":"Beijing Key Laboratory of Plant Resources Research and Development School of Science Beijing Technology and Business University Beijing 100048 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Jia","sequence":"additional","affiliation":[{"name":"School of Science\/Key Laboratory of Cosmetic China National Light Industry Beijing Technology and Business University Beijing 100048 China"},{"name":"Beijing Key Laboratory of Plant Resources Research and Development School of Science Beijing Technology and Business University Beijing 100048 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Cui","sequence":"additional","affiliation":[{"name":"School of Science\/Key Laboratory of Cosmetic China National Light Industry Beijing Technology and Business University Beijing 100048 China"},{"name":"Beijing Key Laboratory of Plant Resources Research and Development School of Science Beijing Technology and Business University Beijing 100048 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Li","sequence":"additional","affiliation":[{"name":"School of Science\/Key Laboratory of Cosmetic China National Light Industry Beijing Technology and Business University Beijing 100048 China"},{"name":"Beijing Key Laboratory of Plant Resources Research and Development School of Science Beijing Technology and Business University Beijing 100048 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"He","sequence":"additional","affiliation":[{"name":"School of Science\/Key Laboratory of Cosmetic China National Light Industry Beijing Technology and Business University Beijing 100048 China"},{"name":"Beijing Key Laboratory of Plant Resources Research and Development School of Science Beijing Technology and Business University Beijing 100048 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12283"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2012.00754.x"},{"key":"e_1_2_6_4_1","first-page":"303","article-title":"Classification of sensitive skin and development of a treatment system appropriate for each group","volume":"6","author":"Yokota T.","year":"2003","journal-title":"IFSCC Mag."},{"key":"e_1_2_6_5_1","first-page":"15","article-title":"Human models for characterizing \u201cSensitive Skin\u201d","volume":"14","author":"Kligman A.","year":"2001","journal-title":"Cosmet. Derm."},{"key":"e_1_2_6_6_1","first-page":"64","article-title":"Advances on the sensitive skin","volume":"35","author":"Li Q.","year":"2013","journal-title":"J. Derm. Venereol."},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00861.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2008.00312.x"},{"key":"e_1_2_6_9_1","first-page":"199","article-title":"Advances in sensitive skin research","volume":"12","author":"Lan Y.","year":"2013","journal-title":"Chin. J. Dermatol. Venereol. Integ. Trad. West Med."},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12245"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12345"},{"key":"e_1_2_6_12_1","article-title":"Application of lipidomics to reveal differences of facial skin surface lipids between male and female","author":"Cui L.","journal-title":"J. Cosmet. Dermatol."},{"key":"e_1_2_6_13_1","first-page":"86","article-title":"Ceramide synthesis and its effects on cells. Foreign Med. Sci. Sect. Clin. Biochem","volume":"25","author":"Zhou W.","year":"2004","journal-title":"Lab. Med."},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2017.11.006"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2004.19.6.859"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-08-3098"},{"key":"e_1_2_6_17_1","first-page":"3175","article-title":"The role of ceramide metabolism in cellular apoptosis and autophagy","volume":"33","author":"Shi F.","year":"2012","journal-title":"Guangdong Med. J."},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112010200"},{"key":"e_1_2_6_19_1","first-page":"609","article-title":"Puerarin inhibits DNA damage of HaCaT cells induced by UVB via ceramide pathway","volume":"47","author":"Huang M.Q.","year":"2012","journal-title":"Acta Pharmaceut. Sin."},{"key":"e_1_2_6_20_1","first-page":"589","article-title":"Advances in glucosylceramide synthase research in multidrug\u2010resistant tumors","volume":"35","author":"Wang Q.","year":"2014","journal-title":"Int. J. Lab. Med."},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117160"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M100442-JLR200"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2005.08.011"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.11.135"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.1751"},{"key":"e_1_2_6_26_1","first-page":"256","article-title":"STAT1 and STAT2 participate in growth inhibition of human hepatoma HepG2 cells induced by phosphatidylethanolamine","volume":"31","author":"Liu L.","year":"2011","journal-title":"J. South Med. Univ."},{"key":"e_1_2_6_27_1","first-page":"1485","article-title":"The role of phosphatidylserine in the autophagy of apoptotic cells","volume":"22","author":"Wang Y.","year":"2006","journal-title":"J. Pract. Med."},{"key":"e_1_2_6_28_1","first-page":"42","article-title":"Physiological function of phosphatidylcholine and its possible mechanism of action","volume":"19","author":"Hu X.","year":"2011","journal-title":"Sci. Technol. Cereals Oils Foods"},{"key":"e_1_2_6_29_1","first-page":"1475","article-title":"Study on lipid change in gastric cancer and the analysis of gastric cancer cell membrane phospholipid variation","volume":"43","author":"Xu F.","year":"2014","journal-title":"Shanxi Med. J."},{"key":"e_1_2_6_30_1","first-page":"513","article-title":"Experimental study of lecithin on the stable state of skin","volume":"17","author":"Yi Y.","year":"2001","journal-title":"Chin. J. Pub. Health"},{"key":"e_1_2_6_31_1","first-page":"511","article-title":"Antioxidant effect of rapeseed lecithin","volume":"27","author":"Yang L.","year":"2013","journal-title":"Military Med. J. South China"},{"key":"e_1_2_6_32_1","first-page":"6454","article-title":"Effects of triglycerides metabolism on HaCaT cells after ultraviolet radiation and its possible mechanism","volume":"14","author":"Jin X.","year":"2014","journal-title":"Progr. Modern Biomed."},{"key":"e_1_2_6_33_1","first-page":"6454","article-title":"Advances in diglyceride research","volume":"19","author":"Chen Y.","year":"2012","journal-title":"Sci. Technol. Inform."},{"key":"e_1_2_6_34_1","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S0022-2275(20)31661-8","article-title":"Diacyglycerol supress high fat dietary induced body fat accumulation in C57BL\/6J mice","volume":"42","author":"Murase T.","year":"2001","journal-title":"J. Lipid Res."},{"key":"e_1_2_6_35_1","unstructured":"Hase T. Murase T. Watanabe H.et\u00a0al.Methods for activating lipid catabolism and improving lipid metabolism in small intestinal epithelium. Patent US:0096866A1 (2003)."}],"container-title":["International Journal of Cosmetic Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fics.12442","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ics.12442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T22:11:37Z","timestamp":1695507097000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ics.12442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,5]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/ics.12442"],"URL":"https:\/\/doi.org\/10.1111\/ics.12442","archive":["Portico"],"relation":{},"ISSN":["0142-5463","1468-2494"],"issn-type":[{"value":"0142-5463","type":"print"},{"value":"1468-2494","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,5]]}}}