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The principle of flow injection analysis (<jats:styled-content style=\"fixed-case\">FIA<\/jats:styled-content>) was applied for sample introduction to an <jats:styled-content style=\"fixed-case\">ESI<\/jats:styled-content>\u2013quadrupole\u2013time of flight mass spectrometer (<jats:styled-content style=\"fixed-case\">ESI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">QTOFMS<\/jats:styled-content>). The carrier solution was composed of water:isopropanol:acetonitrile (20:50:30). From the acquired <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> data, flowgrams of the extracted [M+Na]<jats:sup>+<\/jats:sup> ions were obtained using the following <jats:italic>m\/z<\/jats:italic> values for individual <jats:styled-content style=\"fixed-case\">FAME<\/jats:styled-content>s: 293.2451 (C16:0); 315.2295 (C18:3); 317.2451 (C18:2); 319.2608 (C18:1); 321.2764 (C18:0); 335.2557 (C18:1,<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>); 349.3077 (C20:0); 377.3390 (C22:0) and <jats:italic>m\/z<\/jats:italic> 226.9515 for <jats:styled-content style=\"fixed-case\">IS<\/jats:styled-content>. Baseline\u2010subtracted and filtered signals were integrated, and the list of peaks intensities was exported to Excel, where calibration functions were obtained and quantification carried out. Gas chromatography with a flame ionization detector (<jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">FID<\/jats:styled-content>) was used as an alternative analytical tool.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The calibration detection limits for <jats:styled-content style=\"fixed-case\">FAME<\/jats:styled-content>s of unsaturated fatty acids were in the range 3.61\u20138.62\u00a0\u03bcg\u00a0L<jats:sup>\u22121<\/jats:sup> and for saturated compounds in the range 8.51\u201382.4\u00a0\u03bcg\u00a0L<jats:sup>\u22121<\/jats:sup>. The results obtained for commercial oils were in good agreement with <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">FID<\/jats:styled-content> data; among nine cosmetic oils analysed, three contained low concentrations of ricinoleic acid (C18:1, <jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>), indicating adulteration of castor bean oil with other vegetable oils.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Application of <jats:styled-content style=\"fixed-case\">FIA<\/jats:styled-content> for the sample introduction to <jats:styled-content style=\"fixed-case\">ESI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">QTOFMS<\/jats:styled-content> enabled for reliable determination of <jats:styled-content style=\"fixed-case\">FAME<\/jats:styled-content>s in cosmetic oils with sampling frequency of thirty per hour as compared to two samples per hour achievable using <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">FID<\/jats:styled-content>. The proposed procedure is especially well suited for <jats:styled-content style=\"fixed-case\">FAME<\/jats:styled-content>s of unsaturated fatty acids that are primary components of castor triacylglycerides and contribute to desirable properties of any cosmetic oil.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ics.12465","type":"journal-article","created":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T00:33:42Z","timestamp":1525912422000},"page":"295-302","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Determination of fatty acid methyl esters in cosmetic castor oils by flow injection\u2013electrospray ionization\u2013high\u2010resolution mass spectrometry"],"prefix":"10.1111","volume":"40","author":[{"given":"M. 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