{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:10:15Z","timestamp":1790489415330,"version":"4.1.0"},"reference-count":87,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T00:00:00Z","timestamp":1535068800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2016\/21\/B\/NZ7\/01756"],"award-info":[{"award-number":["2016\/21\/B\/NZ7\/01756"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009045","name":"Uniwersytet Jagiello\u0144ski Collegium Medicum","doi-asserted-by":"publisher","award":["K\/DSC\/004292"],"award-info":[{"award-number":["K\/DSC\/004292"]}],"id":[{"id":"10.13039\/100009045","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intern J of Cosmetic Sci"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cinnamic acid derivatives are widely used in cosmetics and possess various functions. This group of compounds includes both naturally occurring and synthetic substances. On the basis of the Cosmetic Ingredient Database (CosIng) and available literature, this review summarizes their functions in cosmetics, including their physicochemical and biological properties as well as reported adverse effects. A perfuming function is typical of many derivatives of cinnamaldehyde, cinnamyl alcohol, dihydrocinnamyl alcohol and cinnamic acid itself; these substances are commonly used in cosmetics all over the world. Some of them show allergic and photoallergic potential, resulting in restrictions in maximum concentrations and\/or a requirement to indicate the presence of some substances in the list of ingredients when their concentrations exceed certain fixed values in a cosmetic product. Another important function of cinnamic acid derivatives in cosmetics is <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> protection. Ester derivatives such as ethylhexyl methoxycinnamate (octinoxate), isoamyl <jats:italic>p<\/jats:italic>\u2010methoxycinnamte (amiloxiate), octocrylene and cinoxate are used in cosmetics all over the world as <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> filters. However, their maximum concentrations in cosmetic products are restricted due to their adverse effects, which include contact and a photocontact allergies, phototoxic contact dermatitis, contact dermatitis, estrogenic modulation and generation of reactive oxygen species. Other rarely utilized functions of cinnamic acid derivatives are as an antioxidant, in skin conditioning, hair conditioning, as a tonic and in antimicrobial activities. Moreover, some currently investigated natural and synthetic derivatives of cinnamic acid have shown skin lightening and anti\u2010ageing properties. Some of them may become new cosmetic ingredients in the future. In particular, 4\u2010hydroxycinnamic acid, which is currently indexed as a skin\u2010conditioning cosmetics ingredient, has been widely tested <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> as a new drug candidate for the treatment of hyperpigmentation.<\/jats:p>","DOI":"10.1111\/ics.12471","type":"journal-article","created":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T15:59:35Z","timestamp":1528214375000},"page":"356-366","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":158,"title":["Cinnamic acid derivatives in cosmetics: current use and future prospects"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4162-4760","authenticated-orcid":false,"given":"A.","family":"Gunia\u2010Krzy\u017cak","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy Department of Bioorganic Chemistry Chair of Organic Chemistry Jagiellonian University Medical College Medyczna 9 Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"S\u0142oczy\u0144ska","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Department of Pharmaceutical Biochemistry Jagiellonian University Medical College Medyczna 9 Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Popi\u00f3\u0142","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Department of Bioorganic Chemistry Chair of Organic Chemistry Jagiellonian University Medical College Medyczna 9 Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Koczurkiewicz","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Department of Pharmaceutical Biochemistry Jagiellonian University Medical College Medyczna 9 Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Marona","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Department of Bioorganic Chemistry Chair of Organic Chemistry Jagiellonian University Medical College Medyczna 9 Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"P\u0119kala","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Department of Pharmaceutical Biochemistry Jagiellonian University Medical College Medyczna 9 Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/mp\/ssp106"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/biot.200700084"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-052349-1.00034-2"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1081\/SCC-120015773"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.5772\/36489"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/ed067pA304"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3998\/ark.5550190.0008.110"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/10020481"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2015.00116"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-017-8220-x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsyr\/fox091"},{"key":"e_1_2_9_13_1","unstructured":"http:\/\/ec.europa.eu\/growth\/tools-databases\/cosing\/(Accessed January 17 2018)."},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01962.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2002.470107.x"},{"key":"e_1_2_9_16_1","unstructured":"Regulation (EC)No 1223\/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products:https:\/\/ec.europa.eu\/health\/sites\/health\/files\/endocrine_disruptors\/docs\/cosmetic_1223_2009_regulation_en.pdf(Accessed January 17 2018)."},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2004.09.015"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2004.09.012"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2004.09.013"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2007.09.087"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0b013e3182a5d8bc"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000067"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2010.11.010"},{"key":"e_1_2_9_24_1","unstructured":"Scientific Committee on Consumer Products (SCCP)Opinion on cresylpropionaldehyde (p\u2010methyldihydrocinnamaldehyde) (sensitisation only) adopted by the SCCP during the 3rd plenary meeting of March 2005(available from:https:\/\/ec.europa.eu\/health\/ph_risk\/committees\/04_sccp\/docs\/sccp_o_025c.pdf accessed January 10 2018)."},{"key":"e_1_2_9_25_1","unstructured":"Opinion of the Scientific Committee on Cosmetic Products and Non\u2010Food Products intended for consumers concerning an initial list of perfumery materials which must not form part of cosmetic products except subject to the restrictions and conditions laid down(available from:http:\/\/ec.europa.eu\/health\/ph_risk\/committees\/sccp\/documents\/out150_en.pdf accessed January 10 2018)."},{"issue":"2","key":"e_1_2_9_26_1","first-page":"S52","article-title":"A toxicological and dermatological assessment of aryl alkyl alcohols when used as fragrance ingredients","volume":"50","author":"RIFM Expert Panel","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2011.10.044"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2014.05.015"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000087606"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.01.005"},{"key":"e_1_2_9_31_1","unstructured":"http:\/\/ec.europa.eu\/growth\/tools-databases\/cosing\/index.cfm?fuseaction=ref_data.functions(Accessed January 10 2018)"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12165"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12205"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2012.01503.x"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2006.05017"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000079"},{"key":"e_1_2_9_37_1","first-page":"415","article-title":"Photoallergic contact dermatitis due to isoamyl\u2010p\u2010methoxycinnamate","volume":"19","author":"Monz\u00f3n S.","year":"2009","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13003"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.132"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2010.11.002"},{"key":"e_1_2_9_41_1","first-page":"253","article-title":"Sunscreen dermatitis: part II \u2010 The cinnamates","volume":"50","author":"Fisher A.A.","year":"1992","journal-title":"Cutis"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01839.x"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01527.x"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12030"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2006.06.011"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2004.06.043"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2005.05.006"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-002-0348-4"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2005.01.004"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2006.06.016"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph13080782"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2005.12.057"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(03)00203-5"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2006.07.001"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.5650\/jos.50.387"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.2174\/138955712801264792"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22020281"},{"key":"e_1_2_9_58_1","first-page":"403","article-title":"Cinnamic acid derivatives: a new chapter of various pharmacological activities","volume":"3","author":"Sharma P.","year":"2011","journal-title":"J. Chem. Pharm. Res."},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf010830b"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.28.1211"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2012.10.107"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2011.07.064"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-012-0419-x"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.01.061"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules19079655"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2008.10.027"},{"key":"e_1_2_9_67_1","first-page":"4188","article-title":"Synthesis and antioxidant activity of substituted phenylalkene hydroxamic acids","volume":"19","author":"Wagh R.D.","year":"2007","journal-title":"Asian J. Chem."},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules191219292"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2007.11.091"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf0729098"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.01.031"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.2298\/HEMIND130928014S"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08437.x"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0507.2002.00796.x"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2006.09.034"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/skinbio.2011.4"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867323666160627094938"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2004.08.031"},{"key":"e_1_2_9_79_1","first-page":"290","article-title":"Inhibitory effect of p\u2010coumaric acid by Rhodiola sachalinensis on melanin synthesis in B16F10 cells","volume":"63","author":"Park S.H.","year":"2008","journal-title":"Pharmazie."},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1573(199908\/09)13:5<371::AID-PTR453>3.0.CO;2-L"},{"key":"e_1_2_9_81_1","first-page":"913","article-title":"Tyrosinase inhibitory activities of cinnamic acid analogues","volume":"65","author":"Takahashi T.","year":"2010","journal-title":"Pharmazie."},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3095"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08653.x"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2011.03.012"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2010.03983.x"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.03.021"},{"key":"e_1_2_9_87_1","unstructured":"Maignan J.Cosmetic use of cinnamic acid derivatives as lightening agent. WO 2004\/084854 A1 (October 7 2004)."},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-015-1583-x"}],"container-title":["International Journal of Cosmetic Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fics.12471","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ics.12471","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T12:03:07Z","timestamp":1695038587000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ics.12471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":87,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/ics.12471"],"URL":"https:\/\/doi.org\/10.1111\/ics.12471","archive":["Portico"],"relation":{},"ISSN":["0142-5463","1468-2494"],"issn-type":[{"value":"0142-5463","type":"print"},{"value":"1468-2494","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"2018-03-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}