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Recent advances in understanding the biology of hair have accelerated the research and development of novel therapeutic and cosmetic hair growth agents. Preclinical models aid in dermocosmetic efficacy testing and claim substantiation of hair growth modulators. The\n                    <jats:italic>in vitro<\/jats:italic>\n                    models to investigate hair growth utilize the hair follicle Dermal Papilla cells (\n                    <jats:styled-content style=\"fixed-case\">DPC<\/jats:styled-content>\n                    s), specialized mesenchymal cells located at the base of hair follicle that play essential roles in hair follicular morphogenesis and postnatal hair growth cycles. In this review, we have compiled and discussed the extensively reported literature citing\n                    <jats:styled-content style=\"fixed-case\">DPC<\/jats:styled-content>\n                    s as\n                    <jats:italic>in vitro<\/jats:italic>\n                    model to study hair growth promoting and inhibitory effects. A variety of agents such as herbal and natural extracts, growth factors and cytokines, platelet\u2010rich plasma, placental extract, stem cells and conditioned medium, peptides, hormones, lipid\u2010nanocarrier, light, electrical and electromagnetic field stimulation, androgens and their analogs, stress\u2010serum and chemotherapeutic agents etc. have been examined for their hair growth modulating effects in\n                    <jats:styled-content style=\"fixed-case\">DPC<\/jats:styled-content>\n                    s. Effects on\n                    <jats:styled-content style=\"fixed-case\">DPC<\/jats:styled-content>\n                    s\u2019 activity were determined from untreated (basal) or stress induced levels. Cell proliferation, apoptosis and secretion of growth factors were included as primary end\u2010point markers. Effects on a wide range of biomolecules and mechanistic pathways that play key role in the biology of hair growth were also investigated. This consolidated and comprehensive review summarizes the up\u2010to\u2010date information and understanding regarding\n                    <jats:styled-content style=\"fixed-case\">DPC<\/jats:styled-content>\n                    s based screening models for hair growth and may be helpful for researchers to select the appropriate assay system and biomarkers. This review highlights the pivotal role of\n                    <jats:styled-content style=\"fixed-case\">DPC<\/jats:styled-content>\n                    s in the forefront of hair research as screening platforms by providing insights into mechanistic action at cellular level, which may further direct the development of novel hair growth modulators.\n                  <\/jats:p>","DOI":"10.1111\/ics.12489","type":"journal-article","created":{"date-parts":[[2018,8,25]],"date-time":"2018-08-25T09:31:12Z","timestamp":1535189472000},"page":"429-450","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":163,"title":["Review of Hair Follicle Dermal Papilla cells as\n                    <i>in vitro<\/i>\n                    screening model for hair growth"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9315-0232","authenticated-orcid":false,"given":"Alka","family":"Madaan","sequence":"first","affiliation":[{"name":"Cell Biology Lab Dabur Research Foundation 22, Site IV, Sahibabad Ghaziabad Uttar Pradesh 201010 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritu","family":"Verma","sequence":"additional","affiliation":[{"name":"Cell Biology Lab Dabur Research Foundation 22, Site IV, Sahibabad Ghaziabad Uttar Pradesh 201010 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anu T.","family":"Singh","sequence":"additional","affiliation":[{"name":"Cell Biology Lab Dabur Research Foundation 22, Site IV, Sahibabad Ghaziabad Uttar Pradesh 201010 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manu","family":"Jaggi","sequence":"additional","affiliation":[{"name":"Cell Biology Lab Dabur Research Foundation 22, Site IV, Sahibabad Ghaziabad Uttar Pradesh 201010 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4914(01)02027-5"},{"issue":"6","key":"e_1_2_10_3_1","first-page":"5","article-title":"5% Minoxidil: treatment for female pattern hair loss","volume":"19","author":"Gupta A.K.","year":"2014","journal-title":"Skin Therapy Lett."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570163812666150610115055"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004-2730000002923"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(00)00121-8"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12170.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.11.005"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.082446"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13114"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2011.44.8.512"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.01.058"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3844\/ajavsp.2012.104.111"},{"issue":"6","key":"e_1_2_10_14_1","first-page":"262","article-title":"Minoxidil to treat androgenetic alopecia in men and women: what is it & how does it work?","volume":"4","author":"Palanisamy T.","year":"2014","journal-title":"Am. 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