{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:50:53Z","timestamp":1740124253019,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T00:00:00Z","timestamp":1539734400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Unilever Plc."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intern J of Cosmetic Sci"],"published-print":{"date-parts":[[2018,10]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>Zinc pyrithione (ZnPT<\/jats:styled-content>) is widely used as an anti\u2010fungal active in commercial anti\u2010dandruff (AD<\/jats:styled-content>) shampoos. The AD<\/jats:styled-content> efficacy of ZnPT<\/jats:styled-content> is highly dependent on the deposition of ZnPT<\/jats:styled-content> particles onto the scalp during the process of shampoo application and rinse\u2010off. Since ZnPT<\/jats:styled-content> materials with different particle sizes and morphologies have different deposition behaviours, the measurement of the actual ZnPT<\/jats:styled-content> deposition is critical to understand the AD<\/jats:styled-content> performance delivered by different ZnPT<\/jats:styled-content> shampoos. The aim of this study is to develop a robust and reliable method for visualizing the particle size and morphology of ZnPT<\/jats:styled-content> deposited on the scalp from AD<\/jats:styled-content> shampoos.<\/jats:p><\/jats:sec>Methods<\/jats:title>Hair was washed with a commercially available AD<\/jats:styled-content> shampoo containing ZnPT<\/jats:styled-content> and zinc carbonate (ZnCO<\/jats:styled-content>3<\/jats:sub>). Tape strips were applied to collect the deposited particles from the scalp after AD<\/jats:styled-content> shampoo application and rinse\u2010off. The scalp tape strip samples were subjected to scanning electron microscopy\/energy dispersive X\u2010ray spectroscopy (SEM<\/jats:styled-content>\/EDX<\/jats:styled-content>) measurement. The morphology of the ZnPT<\/jats:styled-content> particles was visualized by SEM<\/jats:styled-content> imaging and identification of ZnPT<\/jats:styled-content> particles was confirmed by EDX<\/jats:styled-content> analysis.<\/jats:p><\/jats:sec>Results<\/jats:title>For the commercial shampoo studied it was observed that two zinc\u2010containing particulates with different morphologies and composition remained on the scalp after shampoo application and rinse\u2010off. As indicated by the EDX<\/jats:styled-content> spectra, the ZnPT<\/jats:styled-content> particles deposited onto the scalp surface had polygonal crystal structures. ZnCO<\/jats:styled-content>3<\/jats:sub> was also deposited onto the scalp surface. This material was mainly present as aggregated particulates.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>An ex\u00a0vivo<\/jats:italic> method that combines tape strip sampling and SEM<\/jats:styled-content>\/EDX<\/jats:styled-content> has been developed for measuring and visualizing the particle size, morphology and composition of ZnPT<\/jats:styled-content> deposited on the scalp from AD<\/jats:styled-content> shampoos. This ex\u00a0vivo<\/jats:italic> measurement method provides higher imaging resolution and more chemical specificity than reflectance confocal microscopy (RCM<\/jats:styled-content>). To the best of our knowledge, this is the first time that ZnPT<\/jats:styled-content> particles were distinguishable from other zinc particles on the scalp. Moreover, the new method allows the microstructures of both ZnPT<\/jats:styled-content> and other zinc particles on the scalp to be imaged.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ics.12493","type":"journal-article","created":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T16:14:48Z","timestamp":1536336888000},"page":"530-533","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Visualization of zinc pyrithione particles deposited on the scalp from a shampoo by tape\u2010strip sampling and scanning electron microscopy\/energy dispersive X\u2010ray spectroscopy measurement"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8453-2976","authenticated-orcid":false,"given":"G.","family":"Chen","sequence":"first","affiliation":[{"name":"Unilever Research and Development Shanghai 66 Linxin Road, Linkong Economic Development Zone Shanghai 200335 China"},{"name":"Analytical\u2010Chemistry Group Van \u2018t Hoff Institute for Molecular Sciences University of Amsterdam Science Park 904 1098 XH Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Ji","sequence":"additional","affiliation":[{"name":"Unilever Research and Development Shanghai 66 Linxin Road, Linkong Economic Development Zone Shanghai 200335 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4117-3499","authenticated-orcid":false,"given":"L. Z.","family":"Collins","sequence":"additional","affiliation":[{"name":"Unilever Research and Development Port Sunlight Quarry Road East Bebington Merseyside SH63 3JW U.K"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hoptroff","sequence":"additional","affiliation":[{"name":"Unilever Research and Development Port Sunlight Quarry Road East Bebington Merseyside SH63 3JW U.K"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.\u2010G.","family":"Janssen","sequence":"additional","affiliation":[{"name":"Analytical\u2010Chemistry Group Van \u2018t Hoff Institute for Molecular Sciences University of Amsterdam Science Park 904 1098 XH Amsterdam The Netherlands"},{"name":"Unilever Research and Development Vlaardingen P.O. Box\u00a0114 3130 AC Vlaardingen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12055"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12007"},{"key":"e_1_2_6_4_1","first-page":"140","article-title":"Zinc pyrithione: a topical antimicrobial with complex pharmaceutics","volume":"15","author":"Schwartz J.","year":"2016","journal-title":"J. Drugs Dermatol."},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2015.09.009"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2017.05.031"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10573.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.22.6.066003"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3762\/bjnano.6.25"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000338976"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000066249"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2012.00750.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2011.01.012"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2015.08.002"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.117849"},{"key":"e_1_2_6_16_1","unstructured":"Schwartz J. Johnson E. King B.et\u00a0al.Composition comprising zinc\u2010containing layered material with a high relative zinc lability. US Patent WO 2004\/082647 A1 (2004)."}],"container-title":["International Journal of Cosmetic Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fics.12493","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ics.12493","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T22:47:27Z","timestamp":1694904447000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ics.12493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/ics.12493"],"URL":"https:\/\/doi.org\/10.1111\/ics.12493","archive":["Portico"],"relation":{},"ISSN":["0142-5463","1468-2494"],"issn-type":[{"type":"print","value":"0142-5463"},{"type":"electronic","value":"1468-2494"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"2018-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}