{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T01:17:03Z","timestamp":1760577423506,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T00:00:00Z","timestamp":1545868800000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007190","name":"Unilever","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intern J of Cosmetic Sci"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Sex\u2010related differences in skin properties may be expected to impact dandruff formation and treatment. A meta\u2010analysis approach was undertaken to investigate potential differences between males and females in response to zinc pyrithione (ZnPT) treatment vs. non\u2010anti\u2010dandruff (AD) shampoo. A separate pooled statistical analysis of ceramide and total protein loss endpoints was also undertaken to assess potential sex\u2010related differences in stratum corneum properties that might influence response to ZnPT vs. non\u2010AD shampoo in subjects with dandruff.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The meta\u2010analysis approach included data from 17 half\u2010head, double\u2010blind, randomized studies (<jats:italic>N<\/jats:italic>\u00a0=\u00a02088) undertaken in Asia to assess the effectiveness of 1% ZnPT shampoo and\/or non\u2010AD shampoo in reducing dandruff severity, as assessed by Total Weighted Head Score Adherent Flake (TWHS\u2010AF) methodology. Treatment duration was 4\u00a0weeks, with TWHS\u2010AF measured at weekly intervals. Data from an additional three studies (<jats:italic>N<\/jats:italic>\u00a0=\u00a0143) conducted in Asia were included in the pooled analysis of ceramide levels and protein loss from scalp skin of subjects with dandruff.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Response to 1% ZnPT vs. non\u2010AD shampoo was greater in males than in females at all time points; after 4\u00a0weeks, the between\u2010treatment difference in TWHS\u2010AF was \u221217.5 (95% confidence interval [CI] \u221219.5, \u221215.5) in males and \u221211.1 (\u221213.2, \u22128.9) in females. Sex\u2010related differences were observed between males and females in response to both 1% ZnPT and non\u2010AD shampoos. Males had a stronger response than females to treatment with 1% ZnPT shampoo, while dandruff decreased to a greater extent in females than in males when using non\u2010AD shampoo. Statistically significant sex\u2010related differences in ceramide levels and total protein loss were observed (both <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01). Ceramide levels were 0.76 times lower (95% CI 0.60, 0.97) in males than in females, while total protein loss was 1.4 times greater (95% CI 1.1, 1.9) in males than in females.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Males show a greater response than females to 1% ZnPT shampoo, while females show a greater response than males to non\u2010AD shampoo. These findings may in part be explained by the sex\u2010related differences observed in stratum corneum properties, which may make males more prone to dandruff than females.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ics.12501","type":"journal-article","created":{"date-parts":[[2018,11,17]],"date-time":"2018-11-17T14:54:53Z","timestamp":1542466493000},"page":"583-588","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Sex\u2010related differences in response to zinc pyrithione shampoo vs. non\u2010anti\u2010dandruff shampoo"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4117-3499","authenticated-orcid":false,"given":"L. Z.","family":"Collins","sequence":"first","affiliation":[{"name":"Unilever Research and Development Port Sunlight Laboratory Bebington Merseyside CH63 3JW U.K"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. L.","family":"Baines","sequence":"additional","affiliation":[{"name":"Unilever Research and Development Port Sunlight Laboratory Bebington Merseyside CH63 3JW U.K"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. R.","family":"Matheson","sequence":"additional","affiliation":[{"name":"Unilever Research and Development Port Sunlight Laboratory Bebington Merseyside CH63 3JW U.K"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6051-7947","authenticated-orcid":false,"given":"G. A.","family":"Turner","sequence":"additional","affiliation":[{"name":"Unilever Research and Development Port Sunlight Laboratory Bebington Merseyside CH63 3JW U.K"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Diao","sequence":"additional","affiliation":[{"name":"Unilever Research and Development Centre Shanghai 66 LinXin Road Changning District 200335 Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Li","sequence":"additional","affiliation":[{"name":"Unilever Research and Development Port Sunlight Laboratory Bebington Merseyside CH63 3JW U.K"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Pi","sequence":"additional","affiliation":[{"name":"Unilever Research and Development Centre Shanghai 66 LinXin Road Changning District 200335 Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,27]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"259","volume-title":"Textbook of Cosmetic Dermatology","author":"Schwartz J.","year":"2005"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2494.2006.00326.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2012.00723.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12684"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467-2494.2000.00001.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04629.x"},{"key":"e_1_2_6_8_1","first-page":"154","article-title":"A high\u2010glycerol\u2010containing leave\u2010on scalp care treatment to improve dandruff","volume":"12","author":"Harding C.R.","year":"2014","journal-title":"Skinmed"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-003-0406-7"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-002-0323-1"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12068"},{"key":"e_1_2_6_12_1","unstructured":"Turner G.A.Hair scalp and gender. 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