{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:49:59Z","timestamp":1790912999427,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intern J of Cosmetic Sci"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Tyrosinase is the rate\u2010limiting enzyme in melanogenesis. Thiamidol is the most potent inhibitor of human tyrosinase out of 50\u00a0000 tested compounds. In clinical studies, it was shown to improve facial hyperpigmentation, post\u2010inflammatory hyperpigmentation and age spots significantly. To identify the optimal number of daily Thiamidol applications, we conducted a split\u2010face study comparing the efficacy and tolerability of four\u2010times with two\u2010times daily application. Subsequently, we evaluated the efficacy and tolerability of a typical face care regimen containing Thiamidol in a real\u2010world study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The split\u2010face study was double\u2010blind, randomized, controlled, including two Thiamidol containing products (serum and day care SPF 30). The serum was applied twice daily on one half of the face and the day care SPF30 twice\u2010daily on the whole face. The real\u2010world study was open\u2010label, observational, including three Thiamidol containing products (day care SPF 30 in the morning, serum and night care in the evening). In both studies, subjects with mild\u2010to\u2010moderate facial hyperpigmentation applied the products over 12\u00a0weeks. Assessments included clinical and subjective grading of hyperpigmentation, skin condition, hemi\u2010\/modified MASI, chromameter and clinical photography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the split\u2010face study (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a034), hyperpigmentation, skin roughness and hMASI improved all significantly (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) versus baseline, with first visible results after two weeks of twice\u2010daily application. The four\u2010times daily application led to significant improvement versus the two\u2010times daily application. In the real\u2010world study (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a083), all evaluated parameters, including skin condition and chromametry (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a030), improved significantly (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) in comparison with baseline and the corresponding preceding visits. The subjects judged the cosmetic properties of the products positively. In both studies, the products were well tolerated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Four\u2010times daily Thiamidol improves facial hyperpigmentation significantly more than two\u2010times daily and is well tolerated by the subjects. The real\u2010world study with a typical face care regimen containing Thiamidol shows improvement of facial hyperpigmentation and confirms tolerability. Furthermore, the data provide evidence for the suitability of this three\u2010product Thiamidol regimen for day\u2010to\u2010day life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ics.12626","type":"journal-article","created":{"date-parts":[[2020,5,10]],"date-time":"2020-05-10T22:04:46Z","timestamp":1589148286000},"page":"377-387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Thiamidol containing treatment regimens in facial hyperpigmentation: An international multi\u2010centre approach consisting of a double\u2010blind, controlled, split\u2010face study and of an open\u2010label, real\u2010world study"],"prefix":"10.1111","volume":"42","author":[{"given":"W. G.","family":"Philipp\u2010Dormston","sequence":"first","affiliation":[{"name":"Hautzentrum K\u00f6ln Schillingsrotter Str. 39\u201041 K\u00f6ln 50996 Germany"},{"name":"Faculty of Health University Witten\/Herdecke Witten 58455 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Vila Echag\u00fce","sequence":"additional","affiliation":[{"name":"Centro de Referencia en Tratamiento Laser Av. Del Libertador 662, Piso 17, depto. 42 Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. H.","family":"P\u00e9rez Damonte","sequence":"additional","affiliation":[{"name":"CLAIM Jos\u00e9 Bonifacio 717 Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Riedel","sequence":"additional","affiliation":[{"name":"BDF Argentina Av Triunvirato 2902 Buenos Aires C1427 AAP CABA Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Filbry","sequence":"additional","affiliation":[{"name":"BDF Argentina Av Triunvirato 2902 Buenos Aires C1427 AAP CABA Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Warnke","sequence":"additional","affiliation":[{"name":"BDF Argentina Av Triunvirato 2902 Buenos Aires C1427 AAP CABA Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lofrano","sequence":"additional","affiliation":[{"name":"Beiersdorf AG Unnastrasse 48 Hamburg 20245 Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Roggenkamp","sequence":"additional","affiliation":[{"name":"BDF Argentina Av Triunvirato 2902 Buenos Aires C1427 AAP CABA Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Nippel","sequence":"additional","affiliation":[{"name":"BDF Argentina Av Triunvirato 2902 Buenos Aires C1427 AAP CABA Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007-0963.2001.04556.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03592.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2018.1427874"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-019-00488-w"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.05.009"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms10062440"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2010.00616.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00967"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557519666190116101039"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3002"},{"key":"e_1_2_6_12_1","volume-title":"27th EADV Congress 201","author":"Mann T.","year":"2018"},{"key":"e_1_2_6_13_1","unstructured":"Council Regulation (EC) 1223\/2009 on cosmetic products. 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