{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T03:02:17Z","timestamp":1780628537593,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:00:00Z","timestamp":1599177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intern J of Cosmetic Sci"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Microneedle patches based on dissolving, detachable microneedle technology (Russian patent No. 2652567; US patent EFS No. 32735812; WO\/2019\/231360) are novel dermatological products that allow safe, painless and effective reduction of epidermal wrinkles after six procedures. The purpose of this study was two\u2010fold (a) to assess the safety and efficacy of microneedle patches comprising 650 microneedles containing hyaluronic and ferulic acids after 6 procedures of applying the applicator to the skin for 25\u00a0min; and (b) to correlate our previously reported ex vivo findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The microneedle applicator contains 650 microneedles, which dissolve in 25\u00a0min of exposure. The effectiveness of microneedle applicators was confirmed by a randomized split\u2010phase study involving 82 subjects. Applications of microneedle patches were performed at intervals of two times per week, and the effectiveness was assessed at 6\u00a0weeks after the start of the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results of the profilometric evaluation of skin smoothness demonstrated a significant reduction in the average roughness index by 65.32\u00a0\u00b1\u00a02.99% and in the mean skin waviness by 66.84\u00a0\u00b1\u00a01.6% compared with these indicators in the control group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). The therapeutic effect of the procedure was confirmed by an ultrasound examination that registered a 72.2\u00a0\u00b1\u00a05.4% and 25\u00a0\u00b1\u00a01.4% increase in echo\u2010density of the epidermis and dermis, respectively. An independent blinded skin evaluation by dermatologists revealed steady decrease in puffiness of the application area in 89.9% of patients, increased elasticity in 78.3% of the patients, and reduced severity of epidermal wrinkles in 89.9% of the patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The applicator with 650 soluble microneedles on its surface containing hyaluronic and ferulic acids is considered a safe, effective and convenient way to improve the skin quality in the periorbital region after six procedures. Nevertheless, additional studies of soluble microneedles are required to fully assess the amount and distribution area of the injected hyaluronic acid and other active components, as well as to detail the mechanism of action of soluble microneedles to improve skin quality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ics.12636","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T21:39:57Z","timestamp":1591133997000},"page":"429-435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Microneedle patch based on dissolving, detachable microneedle technology for improved skin quality of the periorbital region. Part 2: Clinical Evaluation"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8131-5650","authenticated-orcid":false,"given":"V.","family":"Zvezdin","sequence":"first","affiliation":[{"name":"Microneedles Inc. 919 North Market Street Wilmington DE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9506-5592","authenticated-orcid":false,"given":"T.","family":"Kasatkina","sequence":"additional","affiliation":[{"name":"Microneedle Industrial LLC 1130\u201042 Bolshoj bulvar Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Kasatkin","sequence":"additional","affiliation":[{"name":"Microneedle Industrial LLC 1130\u201042 Bolshoj bulvar Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gavrilova","sequence":"additional","affiliation":[{"name":"Medlife LLC Perm Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Kazakova","sequence":"additional","affiliation":[{"name":"Medlife LLC Perm Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,4]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"18","article-title":"Microneedles : An Innovative Approach to Transdermal Delivery \u2010 A Review","volume":"6","author":"Akhtar N.","year":"2014","journal-title":"Int. J. Pharm. Pharm. Sci."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.2011.01369.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425241003628171"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi.127.655"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics7030090"},{"key":"e_1_2_8_7_1","first-page":"36","article-title":"Microneedling therapy for atrophic acne scars an objective evaluation","volume":"8","author":"El\u2010Domyati M.","year":"2015","journal-title":"J. Clin. Aesthet. Dermatol."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12723"},{"key":"e_1_2_8_9_1","first-page":"12","article-title":"Acne scarring\u2010pathogenesis, evaluation, and treatment options","volume":"10","author":"Connolly D.","year":"2017","journal-title":"J. Clin. Aesthet. Dermatol."},{"key":"e_1_2_8_10_1","first-page":"50","article-title":"Practical evaluation and management of atrophic acne scars: Tips for the general dermatologist","volume":"4","author":"Fife D.","year":"2011","journal-title":"J. Clin. Aesthet. Dermatol."},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/polb.22259"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12244"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15779"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-017-0269-6"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S142450"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000001474"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.185468"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12546"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.05.003"},{"issue":"1","key":"e_1_2_8_20_1","first-page":"s17","article-title":"Aesthetic treatment considerations for the eyebrows and periorbital complex","volume":"13","author":"Beer K.R.","year":"2014","journal-title":"J. Drugs Dermatol."},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.184049"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.v31.i6.30"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym6020346"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12627"},{"key":"e_1_2_8_25_1","volume-title":"Collagen: Volume II: Biochemistry and Biomechanics","author":"Marcel E.N.","year":"2017"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jccw.2012.11.001"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.58529"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.53096"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22401"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22546"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12453"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12115"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000487401"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12807"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2006.02.017"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.10.078"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.191645"}],"container-title":["International Journal of Cosmetic Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fics.12636","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ics.12636","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ics.12636","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ics.12636","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T00:58:38Z","timestamp":1693961918000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ics.12636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,4]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/ics.12636"],"URL":"https:\/\/doi.org\/10.1111\/ics.12636","archive":["Portico"],"relation":{},"ISSN":["0142-5463","1468-2494"],"issn-type":[{"value":"0142-5463","type":"print"},{"value":"1468-2494","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,4]]},"assertion":[{"value":"2020-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}