{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:34:46Z","timestamp":1788388486760,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T00:00:00Z","timestamp":1599436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intern J of Cosmetic Sci"],"published-print":{"date-parts":[[2020,12]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n \n The human scalp harbours a vast community of microbiotal mutualists. Androgenetic alopecia (AGA), the most common form of hair loss in males, is a multifactorial condition involving genetic predisposition and hormonal changes. The role of microflora during hair loss remains to be understood. After having characterized the scalp microbiota of 12 healthy male subjects and 12 AGA male subjects (D0), the aim of this investigation was to evaluate the capacity of\n Lindera strychnifolia<\/jats:italic>\n root extract (LsR) to restore a healthy bacterial and fungal scalp microflora after 83\u00a0days (D83) of treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Material and methods<\/jats:title>\n \n The strategy used was based on high\u2010throughput DNA sequencing targeting the encoding 16S ribosomal RNA for bacteria and\n Internal Transcribed Spacer 1<\/jats:italic>\n ribosomal DNA for fungi.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Test analysis of relative abundance comparing healthy and AGA subjects showed a significant increase of\n Cutibacterim acnes<\/jats:italic>\n (\n P<\/jats:italic>\n \u00a0<\u00a00.05) and\n Stenotrophomonas geniculata<\/jats:italic>\n (\n P<\/jats:italic>\n \u00a0<\u00a00.01) in AGA subjects. AGA scalp condition was also associated with a significant (\n P<\/jats:italic>\n \u00a0<\u00a00.05) decrease of\n Staphylococcus epidermidis<\/jats:italic>\n relative abundance. A lower proportion of\n Malassezia<\/jats:italic>\n genus in samples corresponding to AGA scalps and an increase of other bacterial genera (\n Wallemia<\/jats:italic>\n ,\n Eurotium<\/jats:italic>\n ) were also noted. At the species level, mean relative abundance of\n Malassezia restricta<\/jats:italic>\n and\n Malassezia globosa<\/jats:italic>\n were significantly lower (\n P<\/jats:italic>\n \u00a0<\u00a00.05) in the AGA group. Eighty\u2010three days of treatment induced a significant decrease in the relative abundance of\n C.\u00a0acnes<\/jats:italic>\n (\n P<\/jats:italic>\n \u00a0<\u00a00.05) and\n S.\u00a0geniculata<\/jats:italic>\n (\n P<\/jats:italic>\n \u00a0<\u00a00.01).\n S.\u00a0epidermidis<\/jats:italic>\n increased significantly (\n P<\/jats:italic>\n \u00a0<\u00a00.05). At the same time, LsR treatment induced a significant increase in the proportion of\n M.\u00a0restricta<\/jats:italic>\n and\n M.\u00a0globosa<\/jats:italic>\n (\n P<\/jats:italic>\n \u00a0<\u00a00.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Data from sequencing profiling of the scalp microbiota strongly support a different microbial composition of scalp between control and AGA populations. Findings suggest that LsR extract may be a potential remedy for scalp microbiota re\u2010equilibrium.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ics.12657","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T07:31:37Z","timestamp":1598599897000},"page":"615-621","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Characteristics of healthy and androgenetic alopecia scalp microbiome: Effect of\n Lindera strychnifolia<\/i>\n roots extract as a natural solution for its modulation"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5127-7486","authenticated-orcid":false,"given":"E.","family":"Filaire","sequence":"first","affiliation":[{"name":"Greentech Biop\u00f4le Clermont\u2010Limagne Saint\u2010Beauzire 63360 France"},{"name":"UMR 1019 INRA\u2010UcA UNH (Human Nutrition Unity) ECREIN Team University Clermont Auvergne Clermont\u2010Ferrand 63000 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4577-4435","authenticated-orcid":false,"given":"A.","family":"Dreux","sequence":"additional","affiliation":[{"name":"Greentech Biop\u00f4le Clermont\u2010Limagne Saint\u2010Beauzire 63360 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4804-9562","authenticated-orcid":false,"given":"C.","family":"Boutot","sequence":"additional","affiliation":[{"name":"Greentech Biop\u00f4le Clermont\u2010Limagne Saint\u2010Beauzire 63360 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3832-9867","authenticated-orcid":false,"given":"E.","family":"Ranouille","sequence":"additional","affiliation":[{"name":"Greentech Biop\u00f4le Clermont\u2010Limagne Saint\u2010Beauzire 63360 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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