{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:29:59Z","timestamp":1790659799839,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intern J of Cosmetic Sci"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Post\u2010inflammatory hyperpigmentation (PIH) is a major cosmetic concern especially in individuals with darker skin complexion. Unfortunately, treatment with anti\u2010inflammatory ingredients alone does not prevent the development of hyperpigmented spots. Recently, isobutylamido\u2010thiazolyl\u2010resorcinol (Thiamidol) was described as a very potent inhibitor of human tyrosinase. The objective of this research was to investigate the potential of this compound to prevent PIH induced by epidermal wounding (suction blister) and related to acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Suction blister\u2010induced PIH was treated with a formulation containing Thiamidol or a vehicle for 3\u00a0months, and the changes in hyperpigmentation were monitored by spectroscopic measurements. The effect of skin care formulations containing Thiamidol on acne\u2010related PIH was investigated in two studies, a vehicle\u2010controlled, double\u2010blinded, randomized clinical study and a clinical observational study. Both studies had a duration of 3\u00a0months and included assessments such as clinical photography, clinical grading and melanin index measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Already after 2\u00a0weeks of treatment, suction blister sites treated with Thiamidol were significantly lighter than control sites and improved throughout the treatment period. Subjects\u00b4 self\u2010grading demonstrated that Thiamidol significantly improved the visibility of acne\u2010induced hyperpigmentation compared to the vehicle treatment. A skin care regimen with Thiamidol significantly improved acne\u2010related PIH over 12\u00a0weeks shown by Mexameter measurements, expert grading, self\u2010grading and clinical photography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Thiamidol represents a safe and effective ingredient for cosmetic products against post\u2010inflammatory hyperpigmentation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ics.12694","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T03:55:08Z","timestamp":1612929308000},"page":"292-301","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Effective reduction of post\u2010inflammatory hyperpigmentation with the tyrosinase inhibitor isobutylamido\u2010thiazolyl\u2010resorcinol (Thiamidol)"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8118-6585","authenticated-orcid":false,"given":"Dennis","family":"Roggenkamp","sequence":"first","affiliation":[{"name":"International Medical Management Eucerin Beiersdorf AG Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ncoza","family":"Dlova","sequence":"additional","affiliation":[{"name":"Nelson R Mandela School of Medicine Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Mann","sequence":"additional","affiliation":[{"name":"Research &amp; Development, Beiersdorf AG Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Batzer","sequence":"additional","affiliation":[{"name":"Research &amp; Development, Beiersdorf AG Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Riedel","sequence":"additional","affiliation":[{"name":"Research &amp; Development, Beiersdorf AG Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Kausch","sequence":"additional","affiliation":[{"name":"Research &amp; Development, Beiersdorf AG Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivica","family":"Zoric","sequence":"additional","affiliation":[{"name":"Research &amp; Development, Beiersdorf AG Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8608-8901","authenticated-orcid":false,"given":"Ludger","family":"Kolbe","sequence":"additional","affiliation":[{"name":"Research &amp; Development, Beiersdorf AG Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2009.08077"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/11536930-000000000-00000"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2009.04.001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19092668"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20142353"},{"issue":"7","key":"e_1_2_7_7_1","first-page":"20","article-title":"Postinflammatory hyperpigmentation: a review of the epidemiology, clinical features, and treatment options in skin of color","volume":"3","author":"Davis E.C.","year":"2010","journal-title":"J. Clin. Aesthet. Dermatol."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13263"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.05305.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2005.40202.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-015-0126-8"},{"key":"e_1_2_7_12_1","volume-title":"Twentyfourth directive 2000\/6\/EG Publication nr L 056","year":"2000"},{"key":"e_1_2_7_13_1","volume-title":"Skin Bleaching Drug Products For Over\u2010the\u2010Counter Human Use","author":"FDA. Department of Health and Human Services. Food and Drug Administration"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.01.019"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19030690"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.02.013"},{"key":"e_1_2_7_17_1","first-page":"751","volume-title":"Sunlight and Man, Normal and Abnormal Photobiological Responses","author":"Fitzpatrick T.B.","year":"1974"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1968.15"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1562\/0031-8655(2003)078<0355:TCOMMA>2.0.CO;2"},{"key":"e_1_2_7_20_1","volume-title":"Standard Guide for Sensory Claim Substantiation","author":"ASTM E1958\u201306","year":"2006"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00029.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2000.01013.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf048340h"},{"key":"e_1_2_7_24_1","first-page":"251e68","article-title":"Mammalian tyrosinase. Stoichiometry and measurement of reaction products","volume":"611","author":"Hearing V.J.","year":"1980","journal-title":"Biochim. Biophys. Acta."},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2012-0300"},{"issue":"7","key":"e_1_2_7_26_1","first-page":"19","article-title":"Racial differences in clinical characteristics, perceptions and behaviors, and psychosocial impact of adult female acne","volume":"7","author":"Callender V.D.","year":"2014","journal-title":"J. Clin. Aesthet. Dermatol."}],"container-title":["International Journal of Cosmetic Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ics.12694","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ics.12694","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ics.12694","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T18:40:36Z","timestamp":1693420836000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ics.12694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,5]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1111\/ics.12694"],"URL":"https:\/\/doi.org\/10.1111\/ics.12694","archive":["Portico"],"relation":{},"ISSN":["0142-5463","1468-2494"],"issn-type":[{"value":"0142-5463","type":"print"},{"value":"1468-2494","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,5]]},"assertion":[{"value":"2020-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}