{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:21:45Z","timestamp":1788909705928,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T00:00:00Z","timestamp":1673481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003052","name":"Ministry of Trade, Industry and Energy","doi-asserted-by":"publisher","award":["P0017747"],"award-info":[{"award-number":["P0017747"]}],"id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intern J of Cosmetic Sci"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Hair loss is caused by various factors. Impacts of these factors are often overlapped and intensified. Currently, mitigation of hair loss is being studied by proliferating dermal papilla cells (DPCs) and inhibiting deleterious factors such as dihydrotestosterone (DHT) and oxidative stress on hair growth.\n                      <jats:italic>Camellia japonica<\/jats:italic>\n                      (\n                      <jats:italic>C.\u00a0japonica<\/jats:italic>\n                      ) fruit shell is a discarded part. Its biological activity remains to be elucidated. In this study, we investigated the capacity of\n                      <jats:italic>C.\u00a0japonica<\/jats:italic>\n                      fruit shell extract (CJFSE) for hair loss mitigation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>MTT assay, spheroid culture and quantitative RT\u2010PCR were performed to observe the proliferative effect of CJFSE on hair follicle dermal papilla cells (HFDPCs). Effects of CJFSE on DHT\u2010induced hair loss were confirmed by Dkk\u20101 ELISA, \u03b2\u2010galactosidase (\u03b2\u2010gal) and 5\u03b1\u2010reductase activity assay. In addition, effects of CJFSE on oxidative stress were confirmed through DPPH and ROS production assays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CJFSE increased the proliferation and spheroid size of HFDPCs. Expression levels of VEGF\u2010A, Wnt\u20101, c\u2010Myc and Cyclin D1 were upregulated by CJFSE. CJFSE also suppressed 5\u03b1\u2010reductase activity and DHT\u2010induced decrease in cell proliferation, Dkk\u20101 secretion and \u03b2\u2010gal activity. Moreover, CJFSE showed DPPH scavenging activity and ameliorated hydrogen peroxide\u2010induced ROS production and \u03b2\u2010gal activity. Finally, gallic acid and protocatechuic acid were observed in CJFSE through HPLC analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CJFSE has the potential to alleviate hair loss by promoting hair cell growth and suppressing effects of DHT and oxidative stress on hair.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ics.12827","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T02:05:27Z","timestamp":1669082727000},"page":"155-165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Assessment of the anti\u2010hair loss potential of\n                    <i>Camellia japonica<\/i>\n                    fruit shell extract in vitro"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9675-9489","authenticated-orcid":false,"given":"Jiyoung","family":"You","sequence":"first","affiliation":[{"name":"Biospectrum Life Science Institute  Yongin\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieun","family":"Woo","sequence":"additional","affiliation":[{"name":"Biospectrum Life Science Institute  Yongin\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung\u2010Baeg","family":"Roh","sequence":"additional","affiliation":[{"name":"Biospectrum Life Science Institute  Yongin\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dehun","family":"Ryu","sequence":"additional","affiliation":[{"name":"Biospectrum Life Science Institute  Yongin\u2010si Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngsu","family":"Jang","sequence":"additional","affiliation":[{"name":"Biospectrum 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