{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T12:08:07Z","timestamp":1770466087947,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T00:00:00Z","timestamp":1691971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intern J of Cosmetic Sci"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dandruff is a common scalp condition affecting almost half of the world's population. Despite its high prevalence, the exact pathophysiology is not well established and is understood to be multifactorial, with factors such as fungal colonization, sebaceous gland activity and individual factors being implicated. There is a need for an effective and safe shampoo that can target the above factors. Hence, we have developed a shampoo formulation with properties of oil control, moisturizing, non\u2010irritative, anti\u2010fungal, anti\u2010microbial and itch\u2010relieving. In this interventional, open\u2010label study, we evaluated the efficacy and safety of this shampoo in reducing the clinical signs of dandruff and pruritus in patients with pre\u2010existing mild\u2010to\u2010moderate dandruff over a course of 21\u2010day treatment duration through self\u2010assessment and objective clinical evaluations. After continued use of the shampoo, there was a significant decrease in the adherent and loose scalp flaking scores. Mean pruritus scores also decreased significantly across the 21\u2010day time points. There were also no adverse events or skin intolerances reported. This study showed that our shampoo formulation has led to a significant reduction in both adherent and loose scalp flaking and pruritus when used in individuals suffering from mild to moderate dandruff. As such, it is an ideal shampoo, which can be used to effectively control dandruff.<\/jats:p>","DOI":"10.1111\/ics.12885","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T10:54:22Z","timestamp":1691146462000},"page":"769-774","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinical efficacy of a gentle anti\u2010dandruff itch\u2010relieving shampoo formulation"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2894-4508","authenticated-orcid":false,"given":"Delwyn Zhi Jie","family":"Lim","sequence":"first","affiliation":[{"name":"National Skin Centre  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei Chu","family":"Lim","sequence":"additional","affiliation":[{"name":"Skin Tree Center  Shah Alam Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong Liang","family":"Tey","sequence":"additional","affiliation":[{"name":"Lee Kong Chian School of Medicine Nanyang Technological University  Singapore Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1087-0024.2005.10103.x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.13188\/2373\u20101044.1000019"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7753.82117"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10570.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058203"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2012.00723.x"},{"key":"e_1_2_12_8_1","unstructured":"Commission Regulation (EU) 2021\/1902.Official Journal of the European Union.2021. L387\/120\u2010387\/125."},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-2130-8"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.07.058"},{"issue":"1","key":"e_1_2_12_11_1","first-page":"1","article-title":"Antimicrobial efficacy of Caprylyl glycol and Ethylhexylglycerine in emulsion","volume":"23","author":"Lawan K","year":"2018","journal-title":"J Health Res"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S219109"},{"issue":"1","key":"e_1_2_12_13_1","first-page":"26","article-title":"Scalp seborrheic dermatitis and dandruff therapy using a herbal and zinc Pyrithione\u2010based therapy of shampoo and scalp lotion","volume":"11","author":"Barak\u2010Shinar D","year":"2018","journal-title":"J Clin Aesthet Dermatol"}],"container-title":["International Journal of Cosmetic Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ics.12885","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T11:45:29Z","timestamp":1702727129000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ics.12885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,14]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/ics.12885"],"URL":"https:\/\/doi.org\/10.1111\/ics.12885","archive":["Portico"],"relation":{},"ISSN":["0142-5463","1468-2494"],"issn-type":[{"value":"0142-5463","type":"print"},{"value":"1468-2494","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,14]]},"assertion":[{"value":"2023-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}