{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T06:35:23Z","timestamp":1780382123727,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intern J of Cosmetic Sci"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Skin cleansing products are among the main reasons for the development of hand eczema. Therefore, a mild but effective skin cleansing product is of particular interest, especially in the work place, where various contaminations frequently have to be removed from hands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, the potential of laureth\u201023 as a primary surfactant was evaluated and compared to other fatty alcohol ethoxylates (FAEO). Also, different laureth\u201023 surfactant combinations were compared to each other. Therefore, transepidermal water loss, erythema and visual scoring were measured after occlusive patch testing in 24 healthy subjects (aged 18\u201355). Afterwards, the results were ranked from low to high irritant potential and an irritation score was calculated. Furthermore, the cleaning performance was tested using an automated cleansing device in 10 healthy subjects (aged 18\u201355).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results confirmed the low irritant potential of laureth\u201023 and blends thereof. Within the different laureth\u201023 surfactant combinations, the combination of laureth\u201023 with a mild amphoteric and a mild anionic surfactant was superior to other laureth\u201023 surfactant combinations like laureth\u201023\/anionic\/anionic regarding skin compatibility as well as cleaning performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, laureth\u201023 showed very good performance as a primary surfactant. Especially, the combination of laureth\u201023, cocamidopropyl betaine and disodium laureth sulfosuccinate was mild to the skin while also showing good cleansing performance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ics.12940","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T06:00:33Z","timestamp":1704866433000},"page":"403-413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Mild but effective skin cleansing\u2014Evaluation of laureth\u201023 as a primary surfactant"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5525-9245","authenticated-orcid":false,"given":"Anja","family":"Dick","sequence":"first","affiliation":[{"name":"Peter Greven Physioderm GmbH  Euskirchen North Rhine Westphalia Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann Josef","family":"Stolz","sequence":"additional","affiliation":[{"name":"Peter Greven GmbH &amp; Co. 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