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The objective of this study is to investigate the potential benefits of applying a combination of skincare ingredients, namely allantoin, bisabolol, D\u2010panthenol and dipotassium glycyrrhizinate (AB5D), in the modulation of inflammatory factors associated with erythema. Additionally, the study aims to elucidate the mechanisms by which these ingredients exert their combined actions to alleviate erythema\u2010associated inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Human epidermal keratinocytes were exposed to UVB and subsequently treated with AB5D. Transcriptomics profiling was performed to analyse the dose\u2013response effect of AB5D treatment on keratinocytes. The quantitation of inflammatory mediators, including PGE<jats:sub>2<\/jats:sub>, IL\u20101\u03b1, IL\u20106, IL\u20108, IL\u20101RA and TNF\u03b1, was performed on cultured media. Additionally, the oxygen radical absorbance capacity (ORAC) assay was carried out to evaluate the total antioxidant capacity of both individual ingredients and the AB5D combination. To assess the in\u2010vitro antioxidant effects of AB5D against UVB\u2010induced oxidative stress in hTERT keratinocytes, real\u2010time quantitation of mitochondrial superoxide was measured through live\u2010cell imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The application of AB5D to UVB\u2010exposed keratinocytes downregulated gene sets associated with inflammatory responses, highlighting the anti\u2010inflammatory properties of AB5D. Specifically, AB5D effectively reduced the production of PGE<jats:sub>2<\/jats:sub>, leading to the downregulation of inflammatory cytokines. Moreover, our findings indicate that AB5D exhibits antioxidative capabilities, functioning as both an antioxidant agent and a regulator of antioxidant enzyme expression to counteract the detrimental effects of cellular oxidative stress.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We demonstrated that AB5D can reduce UVB\u2010induced PGE<jats:sub>2<\/jats:sub>, IL\u20101\u03b1, IL\u20106, IL\u20108, IL\u20101RA and TNF\u03b1 as well as mitochondrial superoxide. These findings suggest that AB5D may alleviate erythema by modulating inflammation via PGE<jats:sub>2<\/jats:sub> and through antioxidation mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ics.12951","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T04:09:40Z","timestamp":1709525380000},"page":"691-701","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The combination of allantoin, bisabolol, D\u2010panthenol and dipotassium glycyrrhizinate mitigates UVB\u2010induced PGE<sub>2<\/sub> synthesis by keratinocytes"],"prefix":"10.1111","volume":"46","author":[{"given":"Chelsea","family":"Tan","sequence":"first","affiliation":[{"name":"Singapore Innovation Center Procter &amp; Gamble  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Peng","sequence":"additional","affiliation":[{"name":"Tian Zhu Kong Gang Development Zone, Beijing 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