{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:29:15Z","timestamp":1759483755741,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intern J of Cosmetic Sci"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p><jats:italic>Magnolia biondii<\/jats:italic>, a plant containing many magnolian\u2010like compounds in its flowers or buds, exhibits anti\u2010inflammatory and antiallergic effects; however, no study has addressed its effect on alleviating ultraviolet light (UV)\u2010induced skin damage. We thus aimed at studying the effects of <jats:italic>M. biondii<\/jats:italic> flower extract (MB) on UVB\u2010induced skin damage and determine the relationship between cell damage and damage\u2010associated molecular patterns (DAMPs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Reconstructed epidermal models and foreskin samples were selected to detect cellular reactions after UVB irradiation and MB treatment. MTT, haematoxylin\u2013eosin and immunofluorescence staining were used to examine total viability, sunburned cells and expression and migration of DAMPs at 16 or 48\u2009h. Prostaglandin E2 (PGE\u20102) and interleukin 8 (IL\u20108) levels were measured using enzyme\u2010linked immunosorbent assays. A clinical UVB\u2010damaged test was carried out on human arms subjected to MB pre\u2010 or post\u2010treatment. Human skin probes were used to measure erythema, melanin, ITA\u00b0 and transepidermal water loss (TEWL), while skin photos were captured using the VISIA system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MB is rich in lignans such as magnolin, pinoresinol dimethyl ether and fargesin, and shows weak UV absorption at 280\u2013320\u2009nm. Coculturing with MB for 16 or 48\u2009h after UVB irradiation improved the tissue viability and structure of Skinovo\u2010Epi, and reduced the expression and migration of high mobility group box protein B1 (HMGB1) as well as the expression of IL\u20108 and PGE\u20102. In the excised foreskin treated with MB after UVB irradiation, the generation of 8\u2010hidroxy\u20102\u2010deoxyguanosine and nuclear transfer of HMGB1 were reduced. When pre\u2010treated with MB for 3\u2009days, UVB\u2010induced skin erythema and ITA\u00b0 were significantly decreased. When post\u2010treated with MB for 5\u2009days, a decrease in skin erythema, melanin and TEWL values and an increase in skin ITA\u00b0 were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment with MB attenuated UVB\u2010induced skin damage, such as erythema, pigmentation and skin barrier function, by improving the tissue viability and structure and reducing sunburned cells and skin inflammation. This effect may be related to DNA damage, which causes the migration of HMGB1 from the nucleus to the outside of the cell to induce skin inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ics.12959","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T05:40:12Z","timestamp":1714455612000},"page":"775-785","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<i>Magnolia biondii<\/i> flower extract attenuates <scp>UVB<\/scp>\u2010induced skin damage through high\u2010mobility group box protein <scp>B1<\/scp>"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8121-7240","authenticated-orcid":false,"given":"Fang","family":"Huang","sequence":"first","affiliation":[{"name":"Technology Innovation Center JAKA Biotech. Co., Ltd.  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Liu","sequence":"additional","affiliation":[{"name":"Technology Innovation Center JAKA Biotech. Co., Ltd.  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4056-5957","authenticated-orcid":false,"given":"Yina","family":"Lu","sequence":"additional","affiliation":[{"name":"Technology Innovation Center JAKA Biotech. Co., Ltd.  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