{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:30:28Z","timestamp":1780083028283,"version":"3.54.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intern J of Cosmetic Sci"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Methylsulfonylmethane (MSM), which contains organic sulphur, has been used for a long time as a medicinal ingredient because of its benefits to human health. MSM is reported to be protective against certain skin disorders, but it is unknown whether it affects melanin synthesis. Therefore, in our current research, we examined the possibility of MSM controlling the production of melanin in Mel\u2010Ab melanocytes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In Mel\u2010Ab cells, melanin contents and tyrosinase activities were assessed and quantified. The expression of microphthalmia\u2010associated transcription factor (MITF) and tyrosinase was evaluated using western blot analysis, while MSM\u2010induced signalling pathways were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The MSM treatment significantly resulted in a dose\u2010dependent increase in melanin production. Furthermore, MSM elevated melanin\u2010related proteins, including MITF and tyrosinase. However, the rate\u2010limiting enzyme of melanin production, tyrosinase, was not directly influenced by it. Therefore, we investigated potential melanogenesis\u2010related signalling pathways that may have been triggered by MSM. Our findings showed that MSM did not influence the signalling pathways associated with glycogen synthase kinase 3\u03b2, cAMP response\u2010element binding protein, extracellular signal\u2010regulated kinase, or p38 mitogen\u2010activated protein kinase. However, MSM phosphorylated c\u2010Jun N\u2010terminal kinases\/stress\u2010activated protein kinase (JNK\/SAPK), which is known to induce melanogenesis. SP600125, a specific JNK inhibitor, inhibited MSM\u2010induced melanogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Taken together, our study indicates that MSM induces melanin synthesis and may serve as a therapeutic option for hypopigmentary skin disorders such as vitiligo.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ics.12988","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T02:23:49Z","timestamp":1719282229000},"page":"918-926","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Methylsulfonylmethane promotes melanogenesis via activation of JNK in Mel\u2010Ab cells"],"prefix":"10.1111","volume":"46","author":[{"given":"In Wook","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Biochemistry Chung\u2010Ang University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo\u2010Jae","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Chung\u2010Ang University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye\u2010Young","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Chung\u2010Ang University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2668-5453","authenticated-orcid":false,"given":"Dong\u2010Seok","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Chung\u2010Ang University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16049"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000506103"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14435"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9030290"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/107555303321222874"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17071123"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2008.00355.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25071537"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28124839"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1586\/edm.10.70"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6810464"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.324657.119"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2016.08.015"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.4196\/kjpp.2014.18.4.307"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.110894"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-009-0994-y"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/792639"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.05.070"},{"issue":"5","key":"e_1_2_8_20_1","first-page":"353","article-title":"A derivative of imidazobenzimidazole, ML106, inhibits melanin synthesis via p38 MAPK activation","volume":"69","author":"Kim SY","year":"2014","journal-title":"Pharmazie"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095186"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000211294"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.1998.tb00736.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.50.31824"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114525"},{"key":"e_1_2_8_26_1","unstructured":"HoT.Skin lightning composition. 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