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Photoaged skin in lightly pigmented individuals, clinically presents with the appearance of wrinkles, increased laxity, and hyper\u2010 and hypopigmentation. Underlying these visible signs of ageing are histological features such as epidermal thinning, dermal\u2013epidermal junction flattening, solar elastosis and loss of the dermal fibrillin microfibrillar network, fibrillar collagen and glycosaminoglycans. Retinoid compounds are comprised of three main generations with the first generation (all\u2010\n                    <jats:italic>trans<\/jats:italic>\n                    retinoic acid, retinol, retinaldehyde and retinyl esters) primarily used for the clinical and cosmetic treatment of photoaging, with varying degrees of efficacy, tolerance and stability. All\u2010\n                    <jats:italic>trans<\/jats:italic>\n                    retinoic acid is considered the \u2018gold standard\u2019 for skin rejuvenation; however, it is a prescription\u2010only product largely confined to clinical use. Therefore, retinoid derivatives are readily incorporated into cosmeceutical formulations. The literature reported in this review suggests that retinol, retinyl esters and retinaldehyde that are used in many cosmeceutical products, are efficacious, safe and well\u2010tolerated. Once in the skin, retinoids utilize a complex signalling pathway that promotes remodelling of photoaged epidermis and dermis and leads to the improvement of the cutaneous signs of photoaging.\n                  <\/jats:p>","DOI":"10.1111\/ics.13013","type":"journal-article","created":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T22:13:58Z","timestamp":1723414438000},"page":"45-57","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Cosmetic retinoid use in photoaged skin: A review of the compounds, their use and mechanisms of action"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8751-1425","authenticated-orcid":false,"given":"Bezaleel","family":"Mambwe","sequence":"first","affiliation":[{"name":"Centre for Dermatology Research Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, The University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kieran T.","family":"Mellody","sequence":"additional","affiliation":[{"name":"Centre for Dermatology Research Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, The University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orsolya","family":"Kiss","sequence":"additional","affiliation":[{"name":"Centre for Dermatology Research Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, The University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"O'Connor","sequence":"additional","affiliation":[{"name":"No7 Beauty Company, Walgreens Boots Alliance  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Bell","sequence":"additional","affiliation":[{"name":"No7 Beauty Company, Walgreens Boots Alliance  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5162-7503","authenticated-orcid":false,"given":"Rachel E. B.","family":"Watson","sequence":"additional","affiliation":[{"name":"Centre for Dermatology Research Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, The University of Manchester  Manchester UK"},{"name":"A*STAR Skin Research Laboratory (A*SRL), Agency for Science, Technology and Research (A*STAR)  Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail K.","family":"Langton","sequence":"additional","affiliation":[{"name":"Centre for Dermatology Research Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, The University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,11]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","first-page":"1","article-title":"Structural and biophysical characteristics of human skin in maintaining proper epidermal barrier function","volume":"33","author":"Boer 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