{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T19:39:43Z","timestamp":1776022783351,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intern J of Cosmetic Sci"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Excessive and unpleasant odours that emanate from the skin can induce bromhidrosis and substantially impair a person's quality of life. Enzymatic pathways generating unpleasant odours are well detailed, and among them, the C\u2013S lyase is one of the enzymes involved in the conversion of non\u2010volatile precursors into thiol\u2010type malodorous volatile molecules such as 3M3SH. This study aimed to investigate the variation of axillary odour intensity correlated with <jats:italic>Staphylococcus<\/jats:italic> (<jats:italic>S<\/jats:italic>.) <jats:italic>hominis<\/jats:italic> C\u2013S lyase activity within a group of volunteers after a physical activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>First, a group of 24 volunteers from the same ethnicity with standardized hygienic and alimentary practices participated in a supervised indoor cycling activity. Following this session, worn T\u2010shirts were recovered to enable the olfactory evaluation of axillary odours by qualified experts. To go further, the microbiota from the axillary zone of each volunteer was sampled and the bacterial relative abundance was investigated by using 16S rRNA metasequencing. Then, <jats:italic>S<\/jats:italic>. <jats:italic>hominis<\/jats:italic> isolates were obtained by culturomics from these microbiota samples and the C\u2013S lyase activity was measured by spectrofluorometry in protein crude extracts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The evaluation of the odour intensity revealed that within the panel, two groups were significantly distinct. A non\u2010odorous group and a malodorous one with volunteers having unpleasant odours. The 16S rRNA metasequencing reveals differences in bacterial communities between the two groups with a significant increase in the relative abundance of <jats:italic>S<\/jats:italic>. <jats:italic>hominis<\/jats:italic> in the malodorous group compared with the non\u2010odorous one. The C\u2013S lyase activities measured on <jats:italic>S<\/jats:italic>. <jats:italic>hominis<\/jats:italic> sampled on volunteers from the two groups demonstrate that for an equivalent quantity of protein, this enzymatic activity is significantly higher for the samples originating from the malodorous group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hence, this study demonstrates that beyond the increase of <jats:italic>S<\/jats:italic>. <jats:italic>hominis<\/jats:italic> relative abundance, the C\u2013S lyase enzymatic activity of this bacteria is also higher in volunteers with unpleasant axillary odours.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ics.13024","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T10:23:24Z","timestamp":1726482204000},"page":"1088-1096","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Identification of a higher C\u2013S 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