{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:56:37Z","timestamp":1791194197274,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intern J of Cosmetic Sci"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Hair loss is a common issue that affects a large proportion of the population, leading to lower self\u2010confidence and quality of life. Microbial dysbiosis of the scalp has been shown to be associated with several different disorders leading to hair loss. Though several \u2018microbiome friendly cosmetic treatments are currently on the market, there is no agreement on the best technique for assessing dysbiosis, leading to a lack of scientific rigour for quantifying the effective treatments. To help address this, the association between self\u2010perceived hair loss and the scalp microbiome in an African\u2010American cohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200936) was investigated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using a self\u2010controlled design, swabs were collected from both \u2018sparse\u2019 and \u2018normal\u2019 scalp sites. The scalp microbiome was characterized via 16S rRNA gene sequencing and a dysbiosis score was calculated based on the proportion of all taxa within the samples. Further, we identified the taxa that contributed most to abnormal or dysbiotic hair sites using a machine learning random forest classifier and a negative binomial mixed\u2010effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The dysbiosis index is sensitive to participants' self\u2010assessment of hair loss and interindividual variation. We found a core set of operational taxonomic units (OTUs) assigned to 7 genera that significantly contributed to increased scalp dysbiosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates that self\u2010perceived hair loss is associated with significant and measurable alterations in the scalp microbiome, making the reported dysbiosis index a practical tool that may be used to assess microbiome changes following cosmetic or medical interventions for hair loss and other microbiome\u2010associated disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ics.70101","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T06:40:58Z","timestamp":1777272058000},"page":"1059-1070","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Scalp microbiome differences in subjects with self\u2010reported hair loss: A quantitative approach to microbial dysbiosis"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7150-1621","authenticated-orcid":false,"given":"Judy","family":"Malas","sequence":"first","affiliation":[{"name":"Department of Biological Sciences University of Illinois Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Reczek","sequence":"additional","affiliation":[{"name":"School of Medicine, Wayne State University  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imani","family":"Porter","sequence":"additional","affiliation":[{"name":"Department of Genetics Stanford University  Stanford California USA"},{"name":"Mane Insights  Naperville Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda 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