{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:01:43Z","timestamp":1786114903150,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008040","name":"Kao Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008040","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intern J of Cosmetic Sci"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To clarify the efficacy of Tuberose Polysaccharide (TPS) as a skin moisturizer and to elucidate its mechanism of action. TPS is known to form a long\u2010lasting, smooth film that protects the stratum corneum (SC) from external stimuli.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 12\u2010week randomized, double\u2010blind, vehicle\u2010controlled, split\u2010face study was conducted using a lotion containing 0.08% TPS combined with an emulsion containing 0.10% TPS, compared to a placebo lotion and emulsion. Skin features, SC components and panelist awareness were evaluated. Additionally, 3D\u2010culture epidermal models treated with 0.50% TPS or vehicle were analysed to determine cytokine levels in the medium and epidermal composition before and after exposure to sodium dodecyl sulfate (SDS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The surface texture of the skin improved faster with TPS treatment compared to the placebo. The capacitance value of the skin increased more from the baseline only in the TPS\u2010treated group. Panelists reported a significantly greater awareness of the efficacy and improvement with TPS compared to the placebo. Cytokine levels in the skin were lower, while intercellular lipids in the SC were higher in the TPS\u2010treated sites compared to the baseline. The ratio of ceramide NP to NS was lower in the placebo\u2010treated sites than in the baseline. Cytokine levels in the medium of the TPS film plus SDS\u2010treated 3D epidermal model were lower than in the vehicle plus SDS\u2010treated epidermal model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TPS supports normal epidermal keratinization by suppressing the cytokines release due to external stimuli by forming a long\u2010lasting smooth film.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ics.70124","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T23:10:18Z","timestamp":1785971418000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A film of tuberose polysaccharide supports normal epidermal keratinization by suppressing cytokine release induced by external stimuli"],"prefix":"10.1111","author":[{"given":"Junko","family":"Ishikawa","sequence":"first","affiliation":[{"name":"Biological Science Research Kao Corporation  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Analytical Science Research, Kao Corporation  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1983.12"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20102494.2008.00459.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.09.004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.2008.08643.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523\u20101747.ep12456950"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2013.12.015"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856\u2010015\u20105410\u2010x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1385\/abab:104:1:13"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2013.05.003"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.661348"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00128630"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00151571"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(95)00563-3"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0176-1617(97)80179-4"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.5107\/sccj.30.77"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.70154"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100846.2007.00242.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1139\/o59\u2010099"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2008.12.010"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523\u20101747.ep12413597"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100625.1998.tb00332.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523\u20101747.ep12371677"},{"key":"e_1_2_9_24_1","doi-asserted-by":"crossref","unstructured":"YokoseU 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