{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T10:32:04Z","timestamp":1786444324939,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intern J of Cosmetic Sci"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Hyperpigmentation is a common skin concern that can significantly impact the quality of life of affected individuals. Managing hyperpigmentation can be challenging due to its recurrent nature, side effects of available treatment options and multiple underlying biological mechanisms contributing to pigment formation and persistence. The tyrosinase inhibitor isobutylamido\u2010thiazolyl\u2010resorcinol (Thiamidol) has proven promising efficacy and safety in several controlled trials. This study sought to evaluate the real\u2010life efficacy and tolerability of thiamidol in an international patient population under real\u2010life conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A multi\u2010national, multi\u2010centre, uncontrolled, open\u2010label study was conducted in 11 European countries. Participants with facial hyperpigmentation were recruited by dermatologists and applied a skincare regimen containing Thiamidol for 12\u2009weeks. Expert assessments were conducted by dermatologists at baseline and after 2, 4, 8 and 12\u2009weeks of application, evaluating parameters such as skin evenness, radiance, smoothness and the modified Melasma Area and Severity Index (mMASI). Additionally, self\u2010assessment by participants was conducted using standardized questionnaires. Statistical analysis was performed to assess relative changes in the examined parameters compared to baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 629 participants completed the study (97,8% women, mean age 47\u2009years, phototypes I\u2013V). Expert grading revealed significant improvements in skin evenness, radiance and smoothness at all time points compared to baseline (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). After 12\u2009weeks, a relative improvement of 91% in skin evenness, 82% in skin radiance and 73% in skin smoothness was observed. The mMASI score decreased significantly, with a reduction of \u221276% after 12\u2009weeks. Overall, improvement of skin condition and tolerability were rated \u2018very good\u2019 in 70.1% and 81.1% of participants, respectively, by their treating dermatologist. Self\u2010assessment confirmed significant improvements in skin hyperpigmentation, evenness, radiance and smoothness, with 97% of participants expressing satisfaction with the Thiamidol\u2010containing skin\u2010care regimen and a desire to continue use.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This real\u2010life study demonstrates the efficacy and tolerability of a Thiamidol\u2010based skincare regimen in managing facial hyperpigmentation. Significant improvements observed in both expert assessments and self\u2010assessment as well as the very good tolerability highlight Thiamidol as a safe and effective cosmetic solution for hyperpigmentation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ics.70127","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T04:32:18Z","timestamp":1783657938000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010world evidence for the efficacy and tolerability of an isobutylamido\u2010thiazolyl\u2010resorcinol (Thiamidol)\u2010containing skincare regimen on facial hyperpigmentation and overall skin appearance: A multi\u2010centre study in 11 European countries"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6411-6318","authenticated-orcid":false,"given":"B.","family":"Schuster","sequence":"first","affiliation":[{"name":"Beiersdorf AG  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0367-2641","authenticated-orcid":false,"given":"T.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Beiersdorf AG  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Vendruscolo","sequence":"additional","affiliation":[{"name":"Beiersdorf AG  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Roggenkamp","sequence":"additional","affiliation":[{"name":"Beiersdorf AG  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. G.","family":"Philipp\u2010Dormston","sequence":"additional","affiliation":[{"name":"Hautzentrum K\u00f6ln\/Cologne Dermatology  Cologne Germany"},{"name":"Faculty of Health University of Witten\/Herdecke  Witten Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Al\u2010Niaimi","sequence":"additional","affiliation":[{"name":"Aalborg University Hospital Aalborg University  Aalborg Denmark"},{"name":"Taktouk Clinic  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Roussel","sequence":"additional","affiliation":[{"name":"Private Practice  Lasne Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9947-1755","authenticated-orcid":false,"given":"N.","family":"Kiss","sequence":"additional","affiliation":[{"name":"5 Department of Dermatology, Venereology and Dermatooncology Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Malik","sequence":"additional","affiliation":[{"name":"Kyiv Municipal Clinical Hospital No. 8  Kyiv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Grozeva","sequence":"additional","affiliation":[{"name":"Derm Clinic Grozeva  Ruse Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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