{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T05:29:03Z","timestamp":1786426143269,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intern J of Cosmetic Sci"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study evaluates room\u2010temperature dual asymmetric centrifugation (DAC) as an R&amp;D scale alternative mixing technology for cosmetic oil\u2010in\u2010water emulsions and structured creams (200\u2009g), compared with high\u2010shear rotor\u2013stator and thermo\u2010mechanical processes, with a focus on product properties and energy requirements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Formulations were characterized by visual assessment, conductivity and pH monitoring over 30\u2009days. Physical stability was analysed by multiple light scattering. Flow and oscillatory measurements were performed, complemented by texture analysis. Specific energy consumption was evaluated at both scales.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All systems exhibited homogeneous oil\u2010in\u2010water structures with no significant differences in pH evolution or physical stability. Shear\u2010thinning behaviour was observed for all formulations, while creams showed dominant elastic behaviour (G\u2032\u2009&gt;\u2009G\u2033), indicating structured networks independent of the mixing process. Texture properties were similar across technologies. Energy analysis revealed a scale effect: rotor\u2013stator was more efficient for 30\u2009g samples, while DAC became competitive at 200\u2009g due to the absence of heating. Final product properties remained comparable across processes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DAC is a robust and energy\u2010efficient alternative for cosmetic emulsions and creams, enabling comparable product properties while offering potential energy savings at larger scales, supporting more sustainable processing strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ics.70130","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T04:53:17Z","timestamp":1786423997000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual asymmetric centrifugation to prepare cosmetic emulsions and creams: Physico\u2010chemical and energy considerations"],"prefix":"10.1111","author":[{"given":"A.","family":"Verger","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Tours, CNRS UPR 4301 CBM, D\u00e9partement NMNS, Facult\u00e9 de Pharmacie  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Azzoug","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Tours, CNRS UPR 4301 CBM, D\u00e9partement NMNS, Facult\u00e9 de Pharmacie  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6691-4484","authenticated-orcid":false,"given":"E.","family":"Munnier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Tours, CNRS UPR 4301 CBM, D\u00e9partement NMNS, Facult\u00e9 de Pharmacie  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"issue":"9","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1016\/j.ces.2005.10.071","article-title":"Effect of mixing protocol on formation of fine emulsions","volume":"61","author":"Sajjadi S","year":"2006","journal-title":"Chem Eng Sci"},{"issue":"3","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/ics.70047","article-title":"Anticipating cosmetic emulsion stability using a novel multi\u2010analytical approach","volume":"48","author":"Viton A","year":"2025","journal-title":"Int J Cosmet Sci"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.ces.2017.07.002","article-title":"On the effect of dispersed phase viscosity and mean residence time on the droplet size distribution for high\u2010shear mixers","volume":"172","author":"Carrillo De Hert S","year":"2017","journal-title":"Chem Eng Sci"},{"issue":"1","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1021\/acs.langmuir.3c02463","article-title":"Droplet size distribution in emulsions","volume":"40","author":"L'Estim\u00e9 M","year":"2024","journal-title":"Langmuir"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cocis.2016.06.014","article-title":"Multilayer emulsions stabilized by vegetable proteins and polysaccharides","volume":"25","author":"Burgos\u2010D\u00edaz C","year":"2016","journal-title":"Curr Opin Colloid Interface Sci"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev-food-030216-025908","article-title":"Edible nanoemulsions as carriers of active ingredients: a review","volume":"8","author":"Salvia\u2010Trujillo L","year":"2017","journal-title":"Annu Rev Food Sci Technol"},{"issue":"5","key":"e_1_2_9_8_1","doi-asserted-by":"crossref","DOI":"10.1208\/s12249-021-02074-y","article-title":"Solid\u2010in\u2010oil\u2010in\u2010water emulsion: an innovative paradigm to improve drug stability and biological activity","volume":"22","author":"Sawant A","year":"2021","journal-title":"AAPS PharmSciTech"},{"key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.foodhyd.2016.08.039","article-title":"Droplet size distribution, rheological behavior and stability of corn oil emulsions stabilized by a novel hydrocolloid (Brea gum) compared with gum arabic","volume":"63","author":"Castel V","year":"2017","journal-title":"Food Hydrocoll"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodhyd.2020.105856","article-title":"Influence of clustering of protein\u2010stabilised oil droplets with proanthocyanidins on mechanical, tribological and sensory properties of O\/W emulsions and emulsion\u2010filled gels","volume":"105","author":"Fuhrmann PL","year":"2020","journal-title":"Food Hydrocoll"},{"issue":"9","key":"e_1_2_9_11_1","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics12090864","article-title":"The influence of co\u2010surfactants on lamellar liquid crystal structures formed in creams","volume":"12","author":"Ahmadi D","year":"2020","journal-title":"Pharmaceutics"},{"issue":"1","key":"e_1_2_9_12_1","doi-asserted-by":"crossref","DOI":"10.1186\/s40538-022-00371-7","article-title":"Rheological, textural and structural properties of dairy cream as affected by some natural stabilizers","volume":"9","author":"Biglarian N","year":"2022","journal-title":"Chem Biol Technol Agric"},{"issue":"4","key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/ics.12302","article-title":"Comparison between sensory and instrumental characterization of topical formulations: impact of thickening agents","volume":"38","author":"Estanqueiro M","year":"2016","journal-title":"Int J Cosmet Sci"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1146\/annurev-food-032818-121501","article-title":"Emulsion formation by homogenization: current understanding and future perspectives","volume":"10","author":"H\u00e5kansson A","year":"2019","journal-title":"Annu Rev Food Sci Technol"},{"issue":"4","key":"e_1_2_9_15_1","doi-asserted-by":"crossref","DOI":"10.5539\/ijc.v8n4p52","article-title":"The effect of high shear homogenization on physical stability of emulsions","volume":"8","author":"Silva T","year":"2016","journal-title":"Int J Chem"},{"issue":"6","key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.3390\/pharmaceutics16060773","article-title":"The effect of process parameters on the microstructure, stability, and sensorial properties of an emulsion cream formulation","volume":"16","author":"Chow PS","year":"2024","journal-title":"Pharmaceutics"},{"issue":"5","key":"e_1_2_9_17_1","doi-asserted-by":"crossref","DOI":"10.3390\/cosmetics10050132","article-title":"Sustainability by reduced energy consumption during manufacturing: the case of cosmetic emulsions","volume":"10","author":"Tamburic S","year":"2023","journal-title":"Cosmetics"},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.colsurfa.2019.01.019","article-title":"Fat crystallization and melting in W\/O\/W double emulsions: comparison between bulk and emulsified state","volume":"566","author":"Nelis V","year":"2019","journal-title":"Colloids Surf A Physicochem Eng Asp"},{"issue":"6","key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1111\/ics.13004","article-title":"Predicting tactile sensory attributes of personal care emulsions based on instrumental characterizations: a review","volume":"46","author":"Akanny E","year":"2024","journal-title":"Int J Cosmet Sci"},{"key":"e_1_2_9_20_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclepro.2023.138259","article-title":"A digital life\u2010cycle management framework for sustainable smart manufacturing in energy intensive industries","volume":"419","author":"Kaniappan Chinnathai M","year":"2023","journal-title":"J Clean Prod"},{"issue":"7","key":"e_1_2_9_21_1","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1021\/acssuschemeng.4c09289","article-title":"Sustainability and techno\u2010economic assessment of batch and flow chemistry in seven industrial pharmaceutical processes","volume":"13","author":"Ince MC","year":"2025","journal-title":"ACS Sustain Chem Eng"},{"issue":"1","key":"e_1_2_9_22_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jconrel.2007.09.010","article-title":"Dual asymmetric centrifugation (DAC)\u2014a new technique for liposome preparation","volume":"125","author":"Massing U","year":"2008","journal-title":"J Control Release"},{"issue":"4","key":"e_1_2_9_23_1","doi-asserted-by":"crossref","DOI":"10.1002\/prep.12039","article-title":"Low solid\u2010loaded formulation homogenization using dual\u2010asymmetric centrifugation","volume":"50","author":"Thornby J","year":"2025","journal-title":"Propellants Explos Pyrotech"},{"issue":"8","key":"e_1_2_9_24_1","doi-asserted-by":"crossref","DOI":"10.1002\/ejlt.201900381","article-title":"Contribution of the internal and external oxygen to the oxidation of microencapsulated fish oil","volume":"122","author":"Linke A","year":"2020","journal-title":"Eur J Lipid Sci Technol"},{"key":"e_1_2_9_25_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cherd.2015.11.016","article-title":"Energy consumption to achieve macromixing revisited","volume":"108","author":"Lin\u00e9 A","year":"2016","journal-title":"Chem Eng Res Des"},{"key":"e_1_2_9_26_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cep.2012.04.004","article-title":"High shear mixers: a review of typical applications and studies on power draw, flow pattern, energy dissipation and transfer properties","volume":"57","author":"Zhang J","year":"2012","journal-title":"Chem Eng Process Process Intensif"},{"key":"e_1_2_9_27_1","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ultsonch.2018.10.003","article-title":"Revision of the mechanisms behind oil\u2010water (O\/W) emulsion preparation by ultrasound and cavitation","volume":"51","author":"Stepi\u0161nik Perdih T","year":"2019","journal-title":"Ultrason Sonochem"},{"issue":"6","key":"e_1_2_9_28_1","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1021\/la035334r","article-title":"Simultaneous conductivity and viscosity measurements as a technique to track emulsion inversion by the phase\u2010inversion\u2010temperature method","volume":"20","author":"Allouche J","year":"2004","journal-title":"Langmuir"},{"issue":"6","key":"e_1_2_9_29_1","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1039\/C0SM00549E","article-title":"Edible nanoemulsions: fabrication, properties, and functional performance","volume":"7","author":"McClements DJ","year":"2011","journal-title":"Soft Matter"},{"issue":"7","key":"e_1_2_9_30_1","doi-asserted-by":"crossref","DOI":"10.3390\/foods10071657","article-title":"The effect of pH and storage temperature on the stability of emulsions stabilized by rapeseed proteins","volume":"10","author":"\u00d6stbring K","year":"2021","journal-title":"Foods"},{"issue":"5","key":"e_1_2_9_31_1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0928-0987(02)00034-9","article-title":"Physicochemical screening of antimicrobial agents as potential preservatives for submicron emulsions","volume":"15","author":"Sznitowska M","year":"2002","journal-title":"Eur J Pharm Sci"},{"issue":"1","key":"e_1_2_9_32_1","article-title":"Effects of pH and electrolytes on Castor oil emulsions with various Stabilisers using Khaya senegalensis gum as an emulsifier","volume":"2021","author":"Kuevi DNO","year":"2021","journal-title":"Adv Pharmacol Pharm Sci"},{"issue":"2","key":"e_1_2_9_33_1","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1021\/acs.molpharmaceut.8b01194","article-title":"Assessing physical stability of colloidal dispersions using a Turbiscan optical analyzer","volume":"16","author":"Sun Y","year":"2019","journal-title":"Mol Pharm"},{"issue":"3","key":"e_1_2_9_34_1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1745-4603.2002.tb01346.x","article-title":"Linear and nonlinear viscoelastic behavior of oil\u2010in\u2010water emulsions stabilized with polysaccharides","volume":"33","author":"Quintana JM","year":"2002","journal-title":"J Texture Stud"},{"key":"e_1_2_9_35_1","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.crfs.2022.03.001","article-title":"Rheological properties of emulsion templated oleogels based on xanthan gum and different structuring agents","volume":"5","author":"Espert M","year":"2022","journal-title":"Curr Res Food Sci"},{"key":"e_1_2_9_36_1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.colsurfa.2013.01.003","article-title":"Rheological and textural characterization of cosmetic emulsions containing natural and synthetic polymers: relationships between both data","volume":"421","author":"Gilbert L","year":"2013","journal-title":"Colloids Surf A Physicochem Eng Asp"},{"issue":"2","key":"e_1_2_9_37_1","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.carbpol.2012.12.028","article-title":"Stretching properties of xanthan, carob, modified guar and celluloses in cosmetic emulsions","volume":"93","author":"Gilbert L","year":"2013","journal-title":"Carbohydr Polym"},{"key":"e_1_2_9_38_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.foodres.2016.01.033","article-title":"Nanoemulsion preparation by combining high pressure homogenization and high power ultrasound at low energy densities","volume":"83","author":"Calligaris S","year":"2016","journal-title":"Food Res Int"},{"key":"e_1_2_9_39_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.fuel.2023.130604","article-title":"Effects of emulsification factors on the characteristics of crude oil emulsions stabilized by chemical and biosurfactants: a review","volume":"361","author":"Al\u2010Sakkaf MK","year":"2024","journal-title":"Fuel"},{"key":"e_1_2_9_40_1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.cherd.2024.02.052","article-title":"Modelling W\/O\/W double emulsions preparation in static mixers: accounting for the shear\u2010thinning behaviour of the dispersed phase","volume":"204","author":"Lebaz N","year":"2024","journal-title":"Chem Eng Res Des"},{"key":"e_1_2_9_41_1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.ces.2019.04.011","article-title":"Numerical and experimental evaluation of droplet breakage of O\/W emulsions in rotor\u2010stator mixers","volume":"204","author":"Gallassi M","year":"2019","journal-title":"Chem Eng Sci"},{"key":"e_1_2_9_42_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.chemolab.2013.03.002","article-title":"Predicting sensory texture properties of cosmetic emulsions by physical measurements","volume":"124","author":"Gilbert L","year":"2013","journal-title":"Chemom Intell Lab Syst"},{"key":"e_1_2_9_43_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fnut.2018.00130","article-title":"Potentialities and limits of some non\u2010thermal technologies to improve sustainability of food processing","volume":"5","author":"Picart\u2010Palmade L","year":"2019","journal-title":"Front Nutr"}],"container-title":["International Journal of Cosmetic Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ics.70130","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ics.70130","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ics.70130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T04:53:24Z","timestamp":1786424004000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ics.70130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,10]]},"references-count":42,"alternative-id":["10.1111\/ics.70130"],"URL":"https:\/\/doi.org\/10.1111\/ics.70130","archive":["Portico"],"relation":{},"ISSN":["0142-5463","1468-2494"],"issn-type":[{"value":"0142-5463","type":"print"},{"value":"1468-2494","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,10]]},"assertion":[{"value":"2026-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ics.70130"}}