{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T06:28:02Z","timestamp":1786343282964,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:00:00Z","timestamp":1786233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:00:00Z","timestamp":1786233600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2024\/08941\u20103"],"award-info":[{"award-number":["2024\/08941\u20103"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003071","name":"Adolphe Merkle Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intern J of Cosmetic Sci"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      The aryl hydrocarbon receptor (AHR) is a regulator of epidermal homeostasis and a promising target for cosmetic and dermatological ingredients aimed at improving skin barrier function and reducing inflammation. This study investigated the potential of the natural polyphenol\n                      <jats:italic>trans<\/jats:italic>\n                      \u2010resveratrol (RSV), a compound of cosmetic interest, to modulate downstream AHR signalling and restore epidermal integrity in a model of skin compromised by a pro\u2010inflammatory environment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A reconstructed human epidermis (RhE) was exposed to a cytokine cocktail (IL\u20104, IL\u201013, TNF\u2010\u03b1) to induce a phenotype mimicking some aspects of atopic eczema, namely inflammation, oxidative stress and barrier disruption, features also prevalent in sensitive and reactive skin conditions. The effects of RSV were evaluated by assessing inflammatory mediators, oxidative stress\u2013related markers, aryl hydrocarbon receptor signalling and epidermal barrier\u2010associated proteins using molecular, biochemical and histological analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Cytokine exposure induced a pronounced inflammatory response, activation of aryl hydrocarbon receptor signalling, oxidative stress\u2013related gene expression and dysregulation of barrier\u2010related markers. Treatment with RSV attenuated the inflamed phenotype by reducing\n                      <jats:italic>IL1A<\/jats:italic>\n                      mRNA expression and IL\u20101\u03b1 secretion, attenuating oxidative stress\u2010associated AHR target gene responses through downregulation of\n                      <jats:italic>CYP1A1<\/jats:italic>\n                      and\n                      <jats:italic>CYP1B1<\/jats:italic>\n                      , while maintaining\n                      <jats:italic>AHR<\/jats:italic>\n                      and\n                      <jats:italic>HMOX1<\/jats:italic>\n                      expression and modulating barrier\u2010associated gene expression, particularly by downregulating\n                      <jats:italic>CASP14<\/jats:italic>\n                      and upregulating the tight junction protein occludin (\n                      <jats:italic>OCLN<\/jats:italic>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings provide mechanistic evidence in a human epidermis model that RSV can counteract inflammation, mitigate oxidative stress and support epidermal barrier homeostasis, actions mediated, at least in part, through modulation of AHR downstream signalling. This supports the potential of resveratrol as a multifunctional active ingredient in cosmetic and dermatological formulations designed to strengthen the skin barrier and calm sensitive or compromised skin.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ics.70134","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T05:31:31Z","timestamp":1786339891000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trans\u2010resveratrol alleviates inflammation and improves skin barrier function via aryl hydrocarbon receptor pathway in human reconstructed epidermis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8206-7430","authenticated-orcid":false,"given":"Irini M.","family":"Dijkhoff","sequence":"first","affiliation":[{"name":"Adolphe Merkle Institute University of Fribourg  Fribourg 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