{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:20:21Z","timestamp":1788351621058,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intern J of Cosmetic Sci"],"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n Type III collagen plays a key role in maintaining skin elasticity and dermal resilience, yet its decline is associated with visible signs of skin ageing. This study aimed to establish a data\u2010driven approach to identify cosmetic peptides with potential to enhance type III collagen through multi\u2010target regulation.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A combined strategy integrating natural language processing (NLP) and knowledge graph (KG) analysis was applied to systematically identify targets associated with type III collagen regulation. Peptides listed in the Inventory of Existing Cosmetic Ingredients in China (IECIC) were screened based on structure\u2010based molecular docking with multiple targets. Candidate peptides were selected for experimental evaluation using human dermal fibroblasts and ex\u00a0vivo skin models.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n By integrating large\u2010scale literature mining with NLP and KG\u2010based gene interaction analysis, we constructed a comprehensive network of genes involved in type III collagen regulation, covering processes such as collagen synthesis, degradation and extracellular matrix (ECM) organization. Based on this network, candidate peptides with predicted multi\u2010target interactions were prioritized through structure\u2010based screening. In\u00a0vitro, four selected peptides\u2014palmitoyl tetrapeptide\u20107, acetyl hexapeptide\u20108, palmitoyl tripeptide\u20101 and palmitoyl tetrapeptide\u201010\u2014significantly increased type III collagen levels following UV exposure, without detectable cytotoxicity. The combination of these peptides exhibited a greater effect than individual components. In ex\u00a0vivo skin tissues, the peptide combination further enhanced the levels of type I, III and IV collagens, indicating a broader modulatory effect on dermal ECM components.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This study provides a practical framework for the identification of cosmetic peptides targeting collagen regulation. The findings support a multi\u2010target approach and suggest that peptide combinations may enhance collagen\u2010related outcomes relevant to skin ageing applications.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ics.70140","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:49:06Z","timestamp":1788349746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanistic understanding and peptide ingredient screening for type\n III<\/scp>\n collagen via biological knowledge graph and molecular docking"],"prefix":"10.1111","author":[{"given":"Shanshan","family":"Zang","sequence":"first","affiliation":[{"name":"L'Oreal (China) Research and Innovation Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Chen","sequence":"additional","affiliation":[{"name":"MetaNovas Biotech Inc. Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9149-3550","authenticated-orcid":false,"given":"Jie","family":"Qiu","sequence":"additional","affiliation":[{"name":"L'Oreal (China) Research and Innovation Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Gu","sequence":"additional","affiliation":[{"name":"L'Oreal (China) Research and Innovation Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Li","sequence":"additional","affiliation":[{"name":"L'Oreal (China) Research and Innovation Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhang","sequence":"additional","affiliation":[{"name":"L'Oreal (China) Research and Innovation Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanze","family":"Wang","sequence":"additional","affiliation":[{"name":"L'Oreal (China) Research and Innovation Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Chen","sequence":"additional","affiliation":[{"name":"L'Oreal (China) Research and Innovation Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Ma","sequence":"additional","affiliation":[{"name":"L'Oreal (China) Research and Innovation Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amiao","family":"Pan","sequence":"additional","affiliation":[{"name":"MetaNovas Biotech Inc. Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Lan","sequence":"additional","affiliation":[{"name":"MetaNovas Biotech Inc. Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lun","family":"Yu","sequence":"additional","affiliation":[{"name":"MetaNovas Biotech Inc. San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijie","family":"Wang","sequence":"additional","affiliation":[{"name":"MetaNovas Biotech Inc. Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7028-3747","authenticated-orcid":false,"given":"Shaohua","family":"Wang","sequence":"additional","affiliation":[{"name":"MetaNovas Biotech Inc. Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2024.1449597","article-title":"Mini review on collagens in normal skin and pathological scars: current understanding and future perspective","volume":"11","author":"Zhou CJ","year":"2024","journal-title":"Front Med"},{"issue":"24","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222413329","article-title":"Main and minor types of collagens in the articular cartilage: the role of collagens in repair tissue evaluation in chondral defects","volume":"22","author":"Alcaide\u2010Ruggiero L","year":"2021","journal-title":"Int J Mol Sci"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.gene.2019.05.003","article-title":"Type III collagen (COL3A1): gene and protein structure, tissue distribution, and associated diseases","volume":"707","author":"Kuivaniemi H","year":"2019","journal-title":"Gene"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.matbio.2019.10.001","article-title":"Type III collagen is a key regulator of the collagen fibrillar structure and biomechanics of articular cartilage and meniscus","volume":"8","author":"Wang C","year":"2020","journal-title":"Matrix Biol"},{"issue":"38","key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"23291","DOI":"10.1074\/jbc.M115.644310","article-title":"Changes in structural\u2010mechanical properties and degradability of collagen during aging\u2010associated modifications","volume":"290","author":"Panwar P","year":"2015","journal-title":"J Biol Chem"},{"issue":"3","key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.3390\/cimb46030132","article-title":"Use of collagen in cosmetic products","volume":"46","author":"Jadach B","year":"2024","journal-title":"Curr Issues Mol Biol"},{"issue":"4","key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"414","DOI":"10.4103\/ijd.ijd_932_22","article-title":"Aging skin and natural bioactives that impede cutaneous aging: a narrative review","volume":"68","author":"Sriram R","year":"2023","journal-title":"Indian J Dermatol"},{"issue":"11","key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"864","DOI":"10.2174\/1389201019666171219105920","article-title":"The importance of some plant extracts as skin anti\u2010aging resources: a review","volume":"18","author":"Yasin ZAM","year":"2017","journal-title":"Curr Pharm Biotechnol"},{"issue":"12","key":"e_1_2_9_10_1","article-title":"Extracellular matrix degradation and remodeling in development and disease","volume":"3","author":"Lu P","year":"2011","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"12","key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1111\/jdv.20286","article-title":"Natural language processing in dermatology: a systematic literature review and state of the art","volume":"38","author":"Paganelli A","year":"2024","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"2","key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1093\/bib\/bbaa012","article-title":"Biological applications of knowledge graph embedding models","volume":"22","author":"Mohamed SK","year":"2021","journal-title":"Brief Bioinform"},{"issue":"4","key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1093\/bioinformatics\/btz682","article-title":"BioBERT: a pre\u2010trained biomedical language representation model for biomedical text mining","volume":"36","author":"Lee J","year":"2020","journal-title":"Bioinformatics"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"D54","DOI":"10.1093\/nar\/gki031","article-title":"Entrez gene: gene\u2010centered information at NCBI","volume":"33","author":"Maglott D","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"e_1_2_9_15_1","unstructured":"LunY DaiT LiH LiaoC TengW HuQ et\u00a0al.Anti\u2010aging skin care formulation development guided by knowledge graph and artificial Intelligence. 33rd IFSCC Congress Barcelona2023."},{"issue":"1","key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein\u2013protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk D","year":"2023","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"e_1_2_9_17_1","doi-asserted-by":"crossref","first-page":"D1373","DOI":"10.1093\/nar\/gkac956","article-title":"PubChem 2023 update","volume":"51","author":"Kim S","year":"2023","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"e_1_2_9_18_1","doi-asserted-by":"crossref","DOI":"10.1186\/s13321-020-00456-1","article-title":"An open source chemical structure curation pipeline using RDKit","volume":"12","author":"Bento AP","year":"2020","journal-title":"J Cheminform"},{"issue":"1","key":"e_1_2_9_19_1","doi-asserted-by":"crossref","DOI":"10.1186\/1758-2946-3-33","article-title":"Open babel: an open chemical toolbox","volume":"3","author":"O'Boyle NM","year":"2011","journal-title":"J Cheminform"},{"issue":"1","key":"e_1_2_9_20_1","doi-asserted-by":"crossref","first-page":"D488","DOI":"10.1093\/nar\/gkac1077","article-title":"RCSB protein data Bank (RCSB.Org): delivery of experimentally\u2010determined PDB structures alongside one million computed structure models of proteins from artificial intelligence\/machine learning","volume":"51","author":"Burley SK","year":"2023","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"e_1_2_9_21_1","doi-asserted-by":"crossref","first-page":"W296","DOI":"10.1093\/nar\/gky427","article-title":"SWISS\u2010MODEL: homology modelling of protein structures and complexes","volume":"46","author":"Waterhouse A","year":"2018","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"e_1_2_9_22_1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13321-018-0285-8","article-title":"P2Rank: machine learning based tool for rapid and accurate prediction of ligand binding sites from protein structure","volume":"10","author":"Kriv\u00e1k R","year":"2018","journal-title":"J Cheminform"},{"issue":"2","key":"e_1_2_9_23_1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1021\/ct100578z","article-title":"PROPKA3: consistent treatment of internal and surface residues in empirical pKaPredictions","volume":"7","author":"Olsson MHM","year":"2011","journal-title":"J Chem Theory Comput"},{"issue":"24","key":"e_1_2_9_24_1","doi-asserted-by":"crossref","first-page":"13045","DOI":"10.1021\/acs.jcim.5c02271","article-title":"Meeko: molecule parametrization and software interoperability for docking and beyond","volume":"65","author":"Santos\u2010Martins D","year":"2025","journal-title":"J Chem Inf Model"},{"issue":"2","key":"e_1_2_9_25_1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott O","year":"2009","journal-title":"J Comput Chem"},{"issue":"5","key":"e_1_2_9_26_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.109708","article-title":"Positive and negative feedback regulation of the TGF\u2010beta1 explains two equilibrium states in skin aging","volume":"27","author":"Haga M","year":"2024","journal-title":"iScience"},{"key":"e_1_2_9_27_1","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1297637","article-title":"The role of cellular senescence in skin aging and age\u2010related skin pathologies","volume":"14","author":"Chin T","year":"2023","journal-title":"Front Physiol"},{"issue":"2","key":"e_1_2_9_28_1","doi-asserted-by":"crossref","DOI":"10.1002\/psc.3668","article-title":"Overview of peptides and their potential roles in skin health and beauty","volume":"31","author":"Wang L","year":"2025","journal-title":"J Pept Sci"},{"issue":"3","key":"e_1_2_9_29_1","doi-asserted-by":"crossref","DOI":"10.3390\/cosmetics12030107","article-title":"Peptides in cosmetics: from pharmaceutical breakthroughs to skincare innovations","volume":"12","author":"Tang Y","year":"2025","journal-title":"Cosmetics"},{"issue":"1","key":"e_1_2_9_30_1","doi-asserted-by":"crossref","first-page":"10474","DOI":"10.1038\/s41598-018-28492-w","article-title":"Effects of collagen\u2010derived bioactive peptides and natural antioxidant compounds on proliferation and matrix protein synthesis by cultured normal human dermal fibroblasts","volume":"8","author":"Edgar S","year":"2018","journal-title":"Sci Rep"},{"issue":"1","key":"e_1_2_9_31_1","doi-asserted-by":"crossref","DOI":"10.3390\/biom15010088","article-title":"Peptides: emerging candidates for the prevention and treatment of skin senescence: a review","volume":"15","author":"Pintea A","year":"2025","journal-title":"Biomolecules"},{"key":"e_1_2_9_32_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2021.104680","article-title":"Collagen peptides and the related synthetic peptides: a review on improving skin health","volume":"86","author":"Zhao X","year":"2021","journal-title":"J Funct Foods"},{"issue":"24","key":"e_1_2_9_33_1","doi-asserted-by":"crossref","DOI":"10.3390\/app142411495","article-title":"Peptides and their mechanisms of action in the skin","volume":"14","author":"Waszkielewicz AM","year":"2024","journal-title":"Appl Sci"},{"issue":"4","key":"e_1_2_9_34_1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.4062\/biomolther.2014.053","article-title":"Dermal stability and in\u00a0vitro skin permeation of collagen Pentapeptides (KTTKS and palmitoyl\u2010KTTKS)","volume":"22","author":"Choi YL","year":"2014","journal-title":"Biomol Ther"},{"issue":"1","key":"e_1_2_9_35_1","doi-asserted-by":"crossref","DOI":"10.1080\/10717544.2023.2284685","article-title":"Lipidization as a tool toward peptide therapeutics","volume":"30","author":"Myskova A","year":"2023","journal-title":"Drug Deliv"},{"issue":"2","key":"e_1_2_9_36_1","doi-asserted-by":"crossref","DOI":"10.3390\/cosmetics4020016","article-title":"Topical peptide treatments with effective anti\u2010aging results","volume":"4","author":"Schagen S","year":"2017","journal-title":"Cosmetics"},{"issue":"1","key":"e_1_2_9_37_1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/ics.70017","article-title":"Evaluation of the sensitive skin syndrome and the effect of a dermo\u2010cosmetic treatment in Thai and polish subjects","volume":"48","author":"Polena H","year":"2026","journal-title":"Int J Cosmet Sci"},{"issue":"4","key":"e_1_2_9_38_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3109\/14764172.2013.769273","article-title":"The anti\u2010wrinkle efficacy of Argireline","volume":"15","author":"Wang Y","year":"2013","journal-title":"J Cosmet Laser Ther"},{"key":"e_1_2_9_39_1","doi-asserted-by":"crossref","DOI":"10.3390\/cosmetics7040091","article-title":"Trending anti\u2010aging peptides","volume":"7","author":"Ferreira MS","year":"2020","journal-title":"Cosmetics"},{"issue":"9","key":"e_1_2_9_40_1","first-page":"BR248","article-title":"Expression of angiotensinogen during hepatic fibrogenesis and its effect on hepatic stellate cells","volume":"17","author":"Lu P","year":"2011","journal-title":"Med Sci Monit"},{"issue":"532","key":"e_1_2_9_41_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/scisignal.aar2566","article-title":"Thrombospondin\u20101 promotes matrix homeostasis by interacting with collagen and lysyl oxidase precursors and collagen cross\u2010linking sites","volume":"11","author":"Rosini S","year":"2018","journal-title":"Sci Signal"},{"issue":"8","key":"e_1_2_9_42_1","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70281","article-title":"Extracellular matrix signaling cues: biological functions, diseases, and therapeutic targets","volume":"6","author":"Zhao T","year":"2025","journal-title":"MedComm"}],"container-title":["International Journal of Cosmetic Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ics.70140","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ics.70140","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ics.70140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:49:19Z","timestamp":1788349759000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ics.70140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,2]]},"references-count":41,"alternative-id":["10.1111\/ics.70140"],"URL":"https:\/\/doi.org\/10.1111\/ics.70140","archive":["Portico"],"relation":{},"ISSN":["0142-5463","1468-2494"],"issn-type":[{"value":"0142-5463","type":"print"},{"value":"1468-2494","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,2]]},"assertion":[{"value":"2026-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ics.70140"}}