{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:34:49Z","timestamp":1790361289565,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,9,23]],"date-time":"2012-09-23T00:00:00Z","timestamp":1348358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Dental Hygiene"],"published-print":{"date-parts":[[2013,2]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>This 3\u2010month double\u2010blind randomized placebo\u2010controlled study evaluated the clinical and microbial effects of an essential oil mouth rinse used as an adjunct to mechanical plaque control by patients in supportive periodontal care.<\/jats:p><\/jats:sec>Material and methods<\/jats:title>Fifty patients were randomly allocated to an essential oil group (L<\/jats:styled-content>isterine\u00ae<\/jats:sup> C<\/jats:styled-content>oolmint; J<\/jats:styled-content>ohnson & J<\/jats:styled-content>ohnson, N<\/jats:styled-content>ew B<\/jats:styled-content>runswick, NJ<\/jats:styled-content>, USA<\/jats:styled-content>) or placebo group to rinse twice per day as an adjunct to mechanical plaque control. At baseline and after 3\u00a0months, plaque index (PI<\/jats:styled-content>), gingivitis index (GI<\/jats:styled-content>), probing pocket depth, bleeding on probing (B<\/jats:styled-content>oP<\/jats:styled-content>) and clinical attachment level were registered. Subgingival plaque samples were collected for the detection and quantification of A<\/jats:styled-content>ggregatibacter actinomycetemcomitans, P<\/jats:styled-content>orphyromonas gingivalis, T<\/jats:styled-content>annerella forsythia, T<\/jats:styled-content>reponema denticola, M<\/jats:styled-content>icromonas micros, P<\/jats:styled-content>revotella intermedia, F<\/jats:styled-content>usobacterium<\/jats:italic> genus and S<\/jats:styled-content>treptococcus mutans<\/jats:italic> by means of real\u2010time PCR<\/jats:styled-content> (qPCR<\/jats:styled-content>). Patient's compliance, satisfaction and side effects were registered.<\/jats:p><\/jats:sec>Results<\/jats:title>Twenty\u2010three patients in the essential oil group (mean age: 57) and 21 in the placebo group (mean age: 55) with acceptable oral hygiene at intake (mean PI<\/jats:styled-content> <1.5 on a scale of 5) adhered to the study protocol. Gingivitis index, PI<\/jats:styled-content> and B<\/jats:styled-content>oP<\/jats:styled-content> significantly reduced over time (P\u00a0<\/jats:italic>\u2264\u00a0<\/jats:italic>0.029); however, between group analyses revealed no significant differences. There was no significant change over time neither in detection frequency nor load for any of the microbiota. Daily rinsing with an essential oil rinse was found safe and perceived beneficial by the patients.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Patients in supportive periodontal care who are fairly compliant with oral hygiene may not benefit from additional mouth rinsing using an essential oil solution.<\/jats:p><\/jats:sec>","DOI":"10.1111\/idh.12000","type":"journal-article","created":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T01:51:20Z","timestamp":1348451480000},"page":"53-61","source":"Crossref","is-referenced-by-count":17,"title":["A double\u2010blind randomized placebo\u2010controlled study on the clinical and microbial effects of an essential oil mouth rinse used by patients in supportive periodontal care"],"prefix":"10.1111","volume":"11","author":[{"given":"J","family":"Cosyn","sequence":"first","affiliation":[{"name":"Department of Periodontology and Oral Implantology Faculty of Medicine and Health Sciences Dental School University of Ghent Ghent Belgium"},{"name":"Faculty of Medicine and Pharmacy, Dental Medicine Free University of Brussels (VUB) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Princen","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Implantology Faculty of Medicine and Health Sciences Dental School University of Ghent Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Miremadi","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Implantology Faculty of Medicine and Health Sciences Dental School University of Ghent Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Decat","sequence":"additional","affiliation":[{"name":"Laboratory Bacteriology Faculty of Medicine and Health Sciences University of Ghent Ghent Belgium"},{"name":"Faculty of Health Care University College Ghent Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Vaneechoutte","sequence":"additional","affiliation":[{"name":"Laboratory Bacteriology Faculty of Medicine and Health Sciences University of Ghent Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"De Bruyn","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Implantology Faculty of Medicine and Health Sciences Dental School University of Ghent Ghent Belgium"},{"name":"Department of Prosthodontics Faculty of Odontology Malm\u00f6 University Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1978.49.5.225"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1982.53.9.539"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1979.50.5.234"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1986.tb01487.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0528.2000.028002112.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00109.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.30.s5.2.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.30.s5.5.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070583"},{"key":"e_1_2_6_11_1","first-page":"259","article-title":"Mouthrinses as adjuncts for plaque and gingivitis management. 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