{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T10:29:43Z","timestamp":1724149783538},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,12,6]],"date-time":"2012-12-06T00:00:00Z","timestamp":1354752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Dental Hygiene"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of the present case series was to evaluate the clinical and microbiological effects of a single session of mechanical and manual scaling and root planing (<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>) combined with the use of two different chlorhexidine formulations in the treatment for generalized chronic periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten patients affected by chronic periodontal disease with periodontal probing depth (<jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>)\u00a0\u2265\u00a05\u00a0mm were treated with <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> plus local chlorhexidine. In each patient, similar teeth, treated with <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> with the adjunctive use of chlorhexidine digluconate and dihydrochloride or chlorhexidine gluconate, respectively, were selected and assigned to a test and a control group. In both groups, <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>, bleeding on probing (<jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content>) parameters, total bacterial counts (<jats:styled-content style=\"fixed-case\">TBC<\/jats:styled-content>) and quality of periodontal bacteria at time 0 and 6\u00a0weeks after treatment were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content> significantly decreased over time both in the test and in the control group; however, no significant differences between the two groups were observed. <jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TBC<\/jats:styled-content> were significantly lower in the test than in the control group 6\u00a0weeks after treatment. In the post\u2010treatment revaluation, a significant decrease both in the treatment and in the control group, for each of the single periodontal pathogens, was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study \u2013 a preliminary case series with small sample size and short follow\u2010up \u2013 the adjunctive use of chlorhexidine (CHX) to <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> resulted in clinical and microbiological benefits in the treatment for generalized chronic periodontitis. A <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content> gel formulation consisting of <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content> digluconate and <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content> dihydrochloride seems to lead some additional benefits over <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> plus <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content> gluconate in the short term. Additional investigations are needed to evaluate the effectiveness of this antiseptic therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/idh.12009","type":"journal-article","created":{"date-parts":[[2012,12,6]],"date-time":"2012-12-06T14:01:26Z","timestamp":1354802486000},"page":"180-185","source":"Crossref","is-referenced-by-count":21,"title":["Adjunctive effect of chlorhexidine antiseptics in mechanical periodontal treatment: first results of a preliminary case series"],"prefix":"10.1111","volume":"11","author":[{"given":"A","family":"Calderini","sequence":"first","affiliation":[{"name":"Department of Dentistry and School of Dental Hygiene, Faculty of Medicine Vita\u2010Salute San Raffaele University, San Raffaele Hospital Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Pantaleo","sequence":"additional","affiliation":[{"name":"Department of Dentistry and School of Dental Hygiene, Faculty of Medicine Vita\u2010Salute San Raffaele University, San Raffaele Hospital Milano Italy"},{"name":"Faculty of Psychology Vita\u2010Salute San Raffaele University, San Raffaele Hospital Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Dentistry and School of Dental Hygiene, Faculty of Medicine Vita\u2010Salute San Raffaele University, San Raffaele Hospital Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Gazzolo","sequence":"additional","affiliation":[{"name":"Department of Dentistry and School of Dental Hygiene, Faculty of Medicine Vita\u2010Salute San Raffaele University, San Raffaele Hospital Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Polizzi","sequence":"additional","affiliation":[{"name":"Department of Dentistry and School of Dental Hygiene, Faculty of Medicine Vita\u2010Salute San Raffaele University, San Raffaele Hospital Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1965.36.3.177"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01681.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1994.tb00020.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.280102.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027009648.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.12968\/denu.2004.31.10.570"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2000.0087"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.29.s3.3.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.29.s3.4.x"},{"key":"e_1_2_6_11_1","first-page":"CD004622","article-title":"Full\u2010mouth disinfection for the treatment of adult chronic periodontitis","volume":"23","author":"Eberhard J","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1992.tb02174.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.280103.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2003.8.1.99"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2003.8.1.79"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050216"},{"key":"e_1_2_6_17_1","first-page":"257","article-title":"Use of chlorhexidine varnishes in preventing and treating periodontal disease. 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