{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T14:29:07Z","timestamp":1772116147455,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Dental Hygiene"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of the study was to compare the antimicrobial activity of a mouth rinse containing chlorhexidine and cetylpyridinium chloride (<jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>1) with a stannous fluoride\u2010based mouth rinse (<jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>2) <jats:italic>in vitro<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Samples of the tongues from 10 subjects with and 10 subjects without halitosis were inoculated on blood agar plates. The agar was perforated, and the cylindrical holes were filled either with mouth rinse <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>1 or with mouth rinse <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>2. After incubation, inhibition zones of the whole tongue microbiota and <jats:italic>Fusobacterium nucleatum<\/jats:italic> were measured. In addition, <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>2 were applied in a short interval killing test (<jats:styled-content style=\"fixed-case\">SIKT<\/jats:styled-content>) on four oral pathogens <jats:italic>Porphyromonas gingivalis<\/jats:italic>,<jats:italic> Prevotella intermedia<\/jats:italic>,<jats:italic> F.\u00a0nucleatum<\/jats:italic> and <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic>. Total viable cell counts were made after two minutes of incubation with increasing concentrations of <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>1 showed a significantly higher <jats:italic>in vitro<\/jats:italic> antimicrobial activity against the whole tongue microbiota and <jats:italic>F.\u00a0nucleatum<\/jats:italic> than <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>2 in both groups of subjects. In the <jats:styled-content style=\"fixed-case\">SIK<\/jats:styled-content> test, <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>1 showed a significantly greater killing capacity than <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>2. The results show that a mouth rinse with low concentrations of chlorhexidine and 0.05% cetylpyridinium chloride appears to be more effective in inhibiting growth of the human tongue microbiota <jats:italic>in vitro<\/jats:italic> than a fluoride\/stannous fluoride\u2010containing mouth rinse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This <jats:italic>in vitro<\/jats:italic> observation supports the use of chlorhexidine and cetylpyridinium chloride in the treatment of oral halitosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/idh.12014","type":"journal-article","created":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T17:15:58Z","timestamp":1359738958000},"page":"203-207","source":"Crossref","is-referenced-by-count":14,"title":["<i>In vitro<\/i> antimicrobial effects of two antihalitosis mouth rinses on oral pathogens and human tongue 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