{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:51:48Z","timestamp":1787014308841,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,11,9]],"date-time":"2014-11-09T00:00:00Z","timestamp":1415491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"GlaxoSmithKline Consumer Healthcare (Hamburg, Germany)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Dental Hygiene"],"published-print":{"date-parts":[[2015,5]]},"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n To evaluate the efficacy of two alcohol\u2010free antimicrobial mouthrinses in reducing plaque and gingivitis compared to an alcohol\u2010containing rinse and toothbrushing alone.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n One hundred and sixty healthy volunteers were enrolled in the randomized controlled trial. Participants were randomly and equally assigned to four groups: (i) toothbrushing\u00a0+\u00a0rinsing (0.06%\n CHX<\/jats:styled-content>\n \u00a0+\u00a00.025% NaF, alcohol\u2010containing rinse, positive control); (ii) toothbrushing + rinsing (0.06%\n CHX<\/jats:styled-content>\n + 0.025% NaF, alcohol\u2010free experimental rinse); (iii) toothbrushing + rinsing (0.06%\n CHX<\/jats:styled-content>\n + 0.03%\n CPC<\/jats:styled-content>\n + 0.025% NaF, alcohol\u2010free experimental rinse); (iv) toothbrushing alone (negative control). At baseline, Quigley\u2010Hein plaque index (\n QHI<\/jats:styled-content>\n ), modified proximal plaque index (\n MPPI<\/jats:styled-content>\n ), and papillary bleeding index (\n PBI<\/jats:styled-content>\n ) were recorded. All subjects brushed their teeth as usual during the study. Additionally, groups 1\u20133 rinsed twice daily. Eight weeks after baseline, indices were recorded again.\n anova<\/jats:sc>\n with Bonferroni adjustment served for statistical analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n One hundred and fifty\u2010five participants were included into final analysis (i:\n n<\/jats:italic>\n \u00a0=\u00a039, 2:\n n<\/jats:italic>\n \u00a0=\u00a039, 3:\n n<\/jats:italic>\n \u00a0=\u00a037, 4:\n n<\/jats:italic>\n \u00a0=\u00a040). Experimental rinses (ii, iii) reduced\n QHI<\/jats:styled-content>\n and\n MPPI<\/jats:styled-content>\n to a higher extent than the negative control (iv), whereas no significant difference to the positive control was found.\n QHI<\/jats:styled-content>\n : (i) 36.6%, (ii) 32.3%, (iii) 36.8%, (iv) 21.6%;\n MPPI<\/jats:styled-content>\n : (i) 11.9%, (ii) 12.2%, (iii) 13.6%, (iv) 3.5%. For\n PBI<\/jats:styled-content>\n , no statistically significant difference was found between groups: (i) 80.2%, (ii) 77.8%, (iii) 76.5% and (iv) 78.8%.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n With respect to\n QHI<\/jats:styled-content>\n and\n MPPI<\/jats:styled-content>\n , toothbrushing in combination with any rinse was more effective than toothbrushing alone. No statistically significant differences were found between the alcohol\u2010free and the alcohol\u2010containing control rinses.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/idh.12111","type":"journal-article","created":{"date-parts":[[2014,11,9]],"date-time":"2014-11-09T21:39:16Z","timestamp":1415569156000},"page":"110-116","source":"Crossref","is-referenced-by-count":10,"title":["Randomized controlled trial on the efficacy of new alcohol\u2010free chlorhexidine mouthrinses after 8\u00a0weeks"],"prefix":"10.1111","volume":"13","author":[{"given":"S","family":"Zimmer","sequence":"first","affiliation":[{"name":"Faculty of Health Department of Operative and Preventive Dentistry Witten\/Herdecke University Witten Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Korte","sequence":"additional","affiliation":[{"name":"Faculty of Health Department of Operative and Preventive Dentistry Witten\/Herdecke University Witten Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Verde","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Coordination Center for Clinical Trials Heinrich\u2010Heine\u2010University D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Ohmann","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Coordination Center for Clinical Trials Heinrich\u2010Heine\u2010University D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Naumova","sequence":"additional","affiliation":[{"name":"Faculty of Health Department of Biological and Material Science in Dentistry Witten\/Herdecke University Witten Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RA","family":"Jordan","sequence":"additional","affiliation":[{"name":"Faculty of Health Department of Operative and Preventive Dentistry Witten\/Herdecke University Witten Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1965.36.3.177"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000259635"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.00414.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01415.x"},{"key":"e_1_2_10_6_1","volume-title":"Vierte Deutsche Mundgesundheitsstudie (DMS IV)","author":"Micheelis W","year":"2006"},{"key":"e_1_2_10_7_1","first-page":"60","article-title":"Removal of dental plaque from different regions of the mouth after a 1\u2010minute episode of mechanical oral hygiene","volume":"24","author":"Prasad KV","year":"2011","journal-title":"Am J Dent"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050362"},{"key":"e_1_2_10_9_1","unstructured":"ICH Topic 6 Guideline for Good Clinical Practice CPMP\/ICH\/135\/95 17th July 1996 and revisions. 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