{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:15:13Z","timestamp":1780485313689,"version":"3.54.1"},"reference-count":69,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T00:00:00Z","timestamp":1433462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"lege artis Pharma GmbH + Co.KG"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Dental Hygiene"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the clinical, microbiological and enzymatic activity of a hydrophobic chlorhexidine\u2010based gingiva\u2010adhering gel containing herbal ingredients, compared with a commercially available 1% chlorhexidine water\u2010soluble gel, during non\u2010surgical therapy of moderate chronic periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 34 subjects participated in this 6\u2010month blinded randomized parallel controlled trial (<jats:styled-content style=\"fixed-case\">ISRCTN<\/jats:styled-content>35210084). After scaling and root planing (<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>), test group received the gel, by rubbing on the gingiva, once every second day, for 14\u00a0days. The control group received the control gel twice daily. Clinical parameters considered were the approximal plaque index, simplified oral hygiene index, modified gingival index, bleeding on probing, probing depth and clinical attachment level (primary outcome), assessed at baseline, 3 and 6\u00a0months, together with the frequency of detection of <jats:italic><jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ggregatibacter actinomycetemcomitans<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>orphyromonas gingivalis<\/jats:italic> (<jats:italic>P.g<\/jats:italic>.), <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>revotella intermedia<\/jats:italic>,<jats:italic> <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reponema denticola<\/jats:italic> (<jats:italic>T.d<\/jats:italic>.), <jats:italic><jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>annerella forsythia<\/jats:italic> (<jats:italic>T.f<\/jats:italic>.), and activity of neutrophil elastase and myeloperoxidase (secondary outcomes).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 3 and 6\u00a0months, all clinical parameters improved significantly, without significant intergroup differences, except <jats:styled-content style=\"fixed-case\">OHI<\/jats:styled-content>\u2010S, which improved at 3\u00a0months (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Microbiological data resulted in no significant intergroup differences at baseline and 6\u00a0months. At 3\u00a0months, significant differences for <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>.g<\/jats:italic>., <jats:italic><jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>.f<\/jats:italic>. and <jats:italic><jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>.d<\/jats:italic>. were noted. A significant reduction of neutrophil elastase after 3 and 6\u00a0months was observed (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.005), without significant intergroup differences. For myeloperoxidase, significant reductions were noted in both groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.005 and <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), but no significant intergroup differences. The tested product seemed to have an increased efficacy, due to longer persistence on the gingiva, with reduced application frequency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both products had a relatively similar influence on the clinical, microbiological and enzymatic outcomes at 3 and 6\u00a0months after <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/idh.12155","type":"journal-article","created":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T20:11:08Z","timestamp":1433535068000},"page":"53-64","source":"Crossref","is-referenced-by-count":17,"title":["Evaluation of a hydrophobic gel adhering to the gingiva in comparison with a standard water\u2010soluble 1% chlorhexidine gel after scaling and root planing in patients with moderate chronic periodontitis. A randomized clinical trial"],"prefix":"10.1111","volume":"15","author":[{"given":"D","family":"Rusu","sequence":"first","affiliation":[{"name":"Department of Periodontology Victor Babes University of Medicine and Pharmacy Timisoara Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u2010I","family":"Stratul","sequence":"additional","affiliation":[{"name":"Department of Periodontology Victor Babes University of Medicine and Pharmacy Timisoara Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Sarbu","sequence":"additional","affiliation":[{"name":"Department of Periodontology Victor Babes University of Medicine and Pharmacy Timisoara Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Roman","sequence":"additional","affiliation":[{"name":"Department of Periodontology Iuliu Hatieganu University of Medicine and Pharmacy Cluj\u2010Napoca 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