{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T09:39:10Z","timestamp":1772357950293,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T00:00:00Z","timestamp":1434585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of\u00a0Surgery, Medical, Molecular and Critical Area Pathology"},{"DOI":"10.13039\/501100007514","name":"University of Pisa","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007514","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Dental Hygiene"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The study was performed to evaluate the incidence of post\u2010surgical adverse events at submerged implant sites as well as the antiplaque, antigingivitis and antistaining effects in the entire dentition of patients treated with two mouthwashes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present randomized controlled clinical study considered 40 patients subjected to dental implant treatment. Two 0.12% chlorhexidine mouthwashes were compared for 15\u00a0days: one with 0.1% hyaluronic acid (<jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content>\u2297<jats:styled-content style=\"fixed-case\">HYL<\/jats:styled-content> group) and one without it (<jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content> group). Surgical outcome variables, and plaque, gingival, and staining indexes were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant differences were found between the two rinses regarding the presence of oedema within 2\u00a0days after surgery (20% for the <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content>\u2297<jats:styled-content style=\"fixed-case\">HYL<\/jats:styled-content> group and 78% for the <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content> group). No other significant differences were recorded between the two mouthwashes. No intergroup differences in plaque, staining and gingivitis indexes were registered. The intragroup analysis revealed that for the plaque and gingival indexes, the differences between the baseline values (before surgery) and those at 15\u00a0days were all found to be significant just for <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content>\u2297<jats:styled-content style=\"fixed-case\">HYL<\/jats:styled-content> rinse, with final values ranging from 0.18 to 0.23 for the plaque index and from 0.06 to 0.07 for the gingival index. The staining index increased for both mouthwash types with significant results (with final value of 0.19 and 0.31 for <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content>\u2297<jats:styled-content style=\"fixed-case\">HYL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content> groups, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the sites of patients subjected to dental implant placement, an additional anti\u2010oedematigenous effect in early healing seemed to be disclosed for 0.12% <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content>\u2297<jats:styled-content style=\"fixed-case\">HYL<\/jats:styled-content> mouthwash. Regarding antiplaque and antigingivitis activities, <jats:styled-content style=\"fixed-case\">HYL<\/jats:styled-content> seemed to be ineffective.<\/jats:p><\/jats:sec>","DOI":"10.1111\/idh.12158","type":"journal-article","created":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T07:10:58Z","timestamp":1434611458000},"page":"65-72","source":"Crossref","is-referenced-by-count":26,"title":["The efficacy of 0.12% chlorhexidine versus 0.12% chlorhexidine plus hyaluronic acid mouthwash on healing of submerged single implant insertion areas: a short\u2010term randomized controlled clinical trial"],"prefix":"10.1111","volume":"15","author":[{"given":"A","family":"Genovesi","sequence":"first","affiliation":[{"name":"Department of Surgery, Medical Molecular and Critical Area Pathology University of Pisa Pisa Italy"},{"name":"Tuscan Stomatologic Institute Versilia General Hospital Lido di Camaiore Lucca 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