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A total of 267 subjects in good general health (\u226518 years), without periodontitis, with at least five teeth per quadrant, and with moderate to advanced gingivitis were enrolled. A 3\u2010week treatment phase was initiated to improve gingival health. Subjects were assigned to one of the six groups: two basic oral hygiene groups (Control I &amp; II), one professional oral hygiene instruction group (OHI), one professional prophylaxis group (PP), an OA&amp;CHX rinse group and a group receiving a combination of all regimens (COMBI group), being OHI + PP + OA&amp;CHX. Dental plaque, gingival bleeding and staining assessments were performed at the start of the treatment phase, at baseline and at 4, 7, 10, and 12 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant reduction in dental plaque\u2010scores for the OA&amp;CHX and COMBI\u2010group (0.51 [SD = 0.37], 0.38 [SD = 0.33] respectively) and a significant reduction in gingivitis scores for the OA&amp;CHX and COMBI group (6.9% [SD = 14.0], 13.4% [SD = 13.4] respectively) from the start of the treatment phase to baseline. No clinically relevant changes were observed for the other four groups. After baseline, bleeding and plaque\u2010scores increased back to a non\u2010significant level between groups, and this level remained throughout the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>OA&amp;CHX and COMBI\u2010group showed a clinically relevant improvement after the treatment phase in terms of dental plaque and gingival bleeding levels. At the 4\u2010month clinical assessment, there was no longer a significant difference between groups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/idh.12213","type":"journal-article","created":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T07:10:52Z","timestamp":1457421052000},"source":"Crossref","is-referenced-by-count":15,"title":["Effectiveness of various interventions on maintenance of gingival health during 1 year \u2013 a randomized clinical trial"],"prefix":"10.1111","volume":"15","author":[{"given":"MPC","family":"Van Leeuwen","sequence":"first","affiliation":[{"name":"Department of Periodontology Academic Center for Dentistry Amsterdam (ACTA) University of Amsterdam and Vrije Universiteit Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NAM","family":"Rosema","sequence":"additional","affiliation":[{"name":"Department of Periodontology Academic Center for Dentistry Amsterdam (ACTA) University of Amsterdam and Vrije Universiteit Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PA","family":"Versteeg","sequence":"additional","affiliation":[{"name":"Department of Periodontology Academic Center for Dentistry Amsterdam (ACTA) University of Amsterdam and Vrije Universiteit Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DE","family":"Slot","sequence":"additional","affiliation":[{"name":"Department of Periodontology Academic Center for Dentistry Amsterdam (ACTA) University of Amsterdam and Vrije Universiteit Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6740-5657","authenticated-orcid":false,"given":"NL","family":"Hennequin\u2010Hoenderdos","sequence":"additional","affiliation":[{"name":"Department of Periodontology Academic Center for Dentistry Amsterdam (ACTA) University of Amsterdam and Vrije Universiteit Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GA","family":"Van der Weijden","sequence":"additional","affiliation":[{"name":"Department of Periodontology Academic Center for Dentistry Amsterdam (ACTA) University of Amsterdam and Vrije Universiteit Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,8]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_9_2_1","DOI":"10.1111\/j.1600-051X.2009.01415.x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_3_1","DOI":"10.1034\/j.1600-051X.2003.00399.x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_4_1","DOI":"10.1034\/j.1600-051X.2003.00414.x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_5_1","DOI":"10.1034\/j.1600-051X.2003.00401.x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_6_1","DOI":"10.1111\/j.1600-051X.2004.00634.x"},{"key":"e_1_2_9_7_1","first-page":"153","volume-title":"Anti\u2010plaque and Anti\u2010calculus Agents","author":"Seymour RA","year":"1992"},{"doi-asserted-by":"publisher","key":"e_1_2_9_8_1","DOI":"10.1111\/j.1601-5037.2012.00557.x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_9_1","DOI":"10.1111\/j.1600-051X.1987.tb02251.x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_10_1","DOI":"10.1111\/j.1600-051X.1989.tb01617.x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_11_1","DOI":"10.1902\/jop.1990.61.11.674"},{"key":"e_1_2_9_12_1","first-page":"38","article-title":"After care of periodontally treated patients","volume":"32","author":"Leu M","year":"1977","journal-title":"Dtsch Zahnarztl Z"},{"key":"e_1_2_9_13_1","first-page":"171","article-title":"The short and long term effect of A\u2010V motivation, motivation by dentist and by dental hygienist","volume":"4","author":"Anerud A","year":"1969","journal-title":"J Periodontal Res"},{"doi-asserted-by":"publisher","key":"e_1_2_9_14_1","DOI":"10.1902\/jop.2008.070654"},{"doi-asserted-by":"publisher","key":"e_1_2_9_15_1","DOI":"10.1111\/j.1600-051X.2004.00595.x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_16_1","DOI":"10.1111\/j.0303-6979.2004.00468.x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_17_1","DOI":"10.1902\/jop.1991.62.3.219"},{"doi-asserted-by":"publisher","key":"e_1_2_9_18_1","DOI":"10.1111\/j.1600-051X.1994.tb00277.x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_19_1","DOI":"10.1111\/j.1600-051X.1996.tb02071.x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_20_1","DOI":"10.1111\/j.1600-0765.1994.tb01217.x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_21_1","DOI":"10.1111\/j.1600-051X.1998.tb02509.x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_22_1","DOI":"10.1034\/j.1600-051x.2001.028010970.x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_23_1","DOI":"10.1111\/j.1600-051X.2009.01495.x"},{"volume-title":"Acceptace Program Guidelines: Council on Scientific Affairs. 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