{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:33:46Z","timestamp":1782282826271,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T00:00:00Z","timestamp":1462838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Dental Hygiene"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to assess the impact of the use of a fluoride toothpaste (Bioxtra<jats:sup>\u00ae<\/jats:sup>, Biopharm, Milan, Italy) with salivary enzymes, essential oils, proteins and colostrum extract versus a fluoride toothpaste without menthol on the oral hygiene grade and on the quality of life (QoL) of children with oral mucositis (<jats:styled-content style=\"fixed-case\">OM<\/jats:styled-content>) grade 1 or 2 receiving chemotherapy for Acute Lymphoblastic Leukaemia (<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients between 6 and 14 years with <jats:styled-content style=\"fixed-case\">OM<\/jats:styled-content> were randomly assigned to two groups, group A (Bioxtra<jats:sup><jats:bold>\u00ae<\/jats:bold><\/jats:sup> toothpaste) and group B (fluoride toothpaste without menthol). The patients were instructed to brush their teeth at least twice a day using a soft toothbrush with a small head. Oral hygiene grade was assessed using the simplified oral hygiene index (<jats:styled-content style=\"fixed-case\">OHI<\/jats:styled-content>\u2010s); quality of life was assessed using the short form of the Oral Health Impact Profile (<jats:styled-content style=\"fixed-case\">OHIP<\/jats:styled-content>\u201014) questionnaires. The patients were evaluated on day 1(diagnosis of <jats:styled-content style=\"fixed-case\">OM<\/jats:styled-content>\u2010T0) and on day 8 (T1). Statistical analysis was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 64 patients were enrolled. A significant difference (<jats:italic>P<\/jats:italic> &lt; 0.001) between the mean of the <jats:styled-content style=\"fixed-case\">OHI<\/jats:styled-content>\u2010s in group A (0.9 \u00b1 1.2) and in group B (1.5 \u00b1 1.3) was found; the overall <jats:styled-content style=\"fixed-case\">OHIP<\/jats:styled-content>\u201014 scores were not associated with the use of one or the other toothpaste (<jats:italic>P<\/jats:italic> = 0.33).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although the use of Bioxtra<jats:sup><jats:bold>\u00ae<\/jats:bold><\/jats:sup> toothpaste does not affect the QoL of children undergoing chemotherapy, it may be recommended as clinically effective in improving the oral hygiene grade.<\/jats:p><\/jats:sec>","DOI":"10.1111\/idh.12226","type":"journal-article","created":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T07:16:41Z","timestamp":1462864601000},"page":"314-319","source":"Crossref","is-referenced-by-count":20,"title":["Oral hygiene grade and quality of life in children with chemotherapy\u2010related oral mucositis: a randomized study on the impact of a fluoride toothpaste with salivary enzymes, essential oils, proteins and colostrum extract versus a fluoride toothpaste without menthol"],"prefix":"10.1111","volume":"14","author":[{"given":"E","family":"Bardellini","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Specialities Radiological Sciences and Public Health Dental School University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Amadori","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Specialities Radiological Sciences and 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