{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:34:35Z","timestamp":1790861675472,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T00:00:00Z","timestamp":1476921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dentaid\u00ae (Cerdanyola del Vall\u00e9s, Barcelona, Spain)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Dental Hygiene"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the effect of two newly formulated chlorhexidine (<jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content>) and cetylpyridinium chloride (<jats:styled-content style=\"fixed-case\">CPC<\/jats:styled-content>) mouthrinses after scaling and root planing (<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>) in terms of clinical, microbiological, patient\u2010based variables and adverse events, with a positive control with the same active components, already marketed and tested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A pilot, randomized clinical trial, double\u2010blind, parallel design with 1\u2010month follow\u2010up was conducted. Chronic periodontitis patients requiring non\u2010surgical periodontal therapy were enrolled and randomly assigned to: (i) <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> and test\u20101 (new reformulation: 0.12% <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content> and 0.05% <jats:styled-content style=\"fixed-case\">CPC<\/jats:styled-content>); (ii) <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> and test\u20102 (new formulation: 0.03% <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content> and 0.05% <jats:styled-content style=\"fixed-case\">CPC<\/jats:styled-content>); or (iii) <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> and positive control (commercial product: 0.12% <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content> and 0.05% <jats:styled-content style=\"fixed-case\">CPC<\/jats:styled-content>). All variables were evaluated at baseline and 1 month after <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>. Quantitative variables were compared by means of <jats:sc>anova<\/jats:sc> or Kruskal\u2013Wallis test and qualitative variables by chi\u2010square or McNemar tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty patients (10 per group) were included. After 1 month, there were significant differences among groups in plaque levels (<jats:italic>P<\/jats:italic> = 0.016) as test\u20101 showed less sites with plaque than test\u20102 (31.15% [standard error\u2010<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content> 2.21%] versus 49.39% [<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content> 4.60%), respectively). No significant differences were found for global patient perception of the product or in adverse effects. Test groups showed better results in levels and proportions (<jats:italic>P<\/jats:italic> = 0.022) of <jats:italic>Capnocytophaga<\/jats:italic> spp.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Within the limitations of this pilot study, it can be concluded that the newly formulated 0.12% <jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content> and 0.05% <jats:styled-content style=\"fixed-case\">CPC<\/jats:styled-content> mouthrinse showed larger plaque level reductions, without showing more adverse effects, when compared to the other two mouthrinses, after <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/idh.12254","type":"journal-article","created":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T06:07:01Z","timestamp":1476943621000},"page":"269-279","source":"Crossref","is-referenced-by-count":22,"title":["Evaluation of new chlorhexidine\u2010 and cetylpyridinium chloride\u2010based mouthrinse formulations adjunctive to scaling and root planing: pilot study"],"prefix":"10.1111","volume":"15","author":[{"given":"M","family":"Garc\u00eda\u2010Gargallo","sequence":"first","affiliation":[{"name":"Section of Graduate Periodontology Faculty of Odontology University Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Zurlohe","sequence":"additional","affiliation":[{"name":"Section of Graduate Periodontology Faculty of Odontology University Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Montero","sequence":"additional","affiliation":[{"name":"Section of Graduate Periodontology Faculty of Odontology University Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Alonso","sequence":"additional","affiliation":[{"name":"Etiology and Therapy of Periodontal Diseases (ETEP) Research Group Faculty of Odontology University Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Serrano","sequence":"additional","affiliation":[{"name":"Etiology and Therapy of Periodontal Diseases (ETEP) Research Group Faculty of Odontology University Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Sanz","sequence":"additional","affiliation":[{"name":"Etiology and Therapy of Periodontal Diseases (ETEP) Research Group Faculty of Odontology University Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Herrera","sequence":"additional","affiliation":[{"name":"Etiology and Therapy of Periodontal Diseases (ETEP) Research Group Faculty of Odontology University Complutense Madrid 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