{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T14:01:44Z","timestamp":1774360904523,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T00:00:00Z","timestamp":1515715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja","doi-asserted-by":"publisher","award":["175075"],"award-info":[{"award-number":["175075"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Dental Hygiene"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>A clinical prospective study was designed to evaluate microbiological, cytomorphometric and clinical efficacy of low\u2010level laser therapy (<jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content>) as an adjunct to periodontal therapy in the treatment of chronic periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty subjects were included and randomly assigned into 2 groups: <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> (scaling root planning) group (n\u00a0=\u00a030) and <jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> group (n\u00a0=\u00a030). Clinical parameters were measured before intervention, after the fifth treatment, and after a month. All subjects received oral hygiene instructions and full\u2010mouth conservative periodontal treatment (removal of dental plaque followed by <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>). Afterwards, in group <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, Kavo <jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content> (980\u00a0nm, 0.2\u00a0W, 6\u00a0J\/cm<jats:sup>2<\/jats:sup>) was applied. Subgingival samples were collected at baseline and after the fifth treatment to quantify <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic>,<jats:italic> Prevotella intermedia<\/jats:italic>,<jats:italic> Porphyromonas gingivalis, Tannerella forsythensis<\/jats:italic> and <jats:italic>Treponema denticola<\/jats:italic> by polymerase chain reaction (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>). Gingival swabs were taken, and direct smears were prepared on slides for cytomorphometric analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Evaluation using clinical parameters showed better results in <jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content> group. A statistically significant decrease in the prevalence of bacteria after treatment in <jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content> group was observed for the following: <jats:italic>T.\u00a0forsythensis<\/jats:italic> and <jats:italic>T.\u00a0denticola<\/jats:italic> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), <jats:italic>P.\u00a0gingivalis<\/jats:italic> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01), <jats:italic>A.\u00a0actinomycetemcomitans<\/jats:italic> and <jats:italic>P<\/jats:italic>.\u00a0<jats:italic>intermedia<\/jats:italic> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). The values of nuclear area, perimeter and Ferret's diameter were significantly lower in both studied groups after treatment, but statistical significance was higher in <jats:styled-content style=\"fixed-case\">LLLT<\/jats:styled-content> group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) than in the <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> therapy group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low\u2010level laser therapy as an adjunct to periodontal therapy demonstrates short\u2010term additional bacteriological, cytological and clinical benefits.<\/jats:p><\/jats:sec>","DOI":"10.1111\/idh.12328","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T07:08:36Z","timestamp":1515740916000},"source":"Crossref","is-referenced-by-count":27,"title":["Clinical, microbiological and cytomorphometric evaluation of low\u2010level laser therapy 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