{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:28:40Z","timestamp":1790242120799,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T00:00:00Z","timestamp":1527033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/10139\u20106"],"award-info":[{"award-number":["2013\/10139\u20106"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2012\/23503\u20105"],"award-info":[{"award-number":["2012\/23503\u20105"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dental Hygiene"],"published-print":{"date-parts":[[2018,11]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>The aim of this randomized double\u2010blind and placebo\u2010controlled study was to assess if periodontal treatment with or without systemic antibiotic would change the mean level of Archaea<\/jats:italic>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Fifty\u2010nine (59) subjects were randomly assigned to receive scaling and root planing (SRP<\/jats:styled-content>) alone or combined with metronidazole (MTZ<\/jats:styled-content>; 400\u00a0mg\/TID) or either with MTZ<\/jats:styled-content> and amoxicillin (AMX<\/jats:styled-content>; 500\u00a0mg\/TID<\/jats:styled-content>) for 14\u00a0days. Clinical and microbiological examinations were performed at baseline and at 6\u00a0months post\u2010SRP<\/jats:styled-content>. Six subgingival plaque samples per subject were analysed for the presence and levels of Archaea<\/jats:italic> using quantitative polymerase chain reaction.<\/jats:p><\/jats:sec>Results<\/jats:title>Scaling and root planing alone or combined with MTZ<\/jats:styled-content> or MTZ<\/jats:styled-content>\u00a0+\u00a0AMX<\/jats:styled-content> significantly reduced the prevalence of subjects colonized by Archaea<\/jats:italic> at 6\u00a0months post\u2010therapy, without significant differences among groups (P<\/jats:italic>\u00a0>\u00a0.05). Both therapies led to a statistically significant decrease in the mean percentage of sites colonized by Archaea<\/jats:italic> (P<\/jats:italic>\u00a0<\u00a0.05). The MTZ<\/jats:styled-content> and MTZ<\/jats:styled-content>\u00a0+\u00a0AMX<\/jats:styled-content> group had a significantly lower mean number of sites colonized by Archaea<\/jats:italic> and lower levels of these micro\u2010organisms at sites with probing depth \u22655\u00a0mm at 6\u00a0months compared with SRP<\/jats:styled-content> group (P<\/jats:italic>\u00a0<\u00a0.05).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Periodontal treatments including adjunctive MTZ<\/jats:styled-content> or MTZ<\/jats:styled-content>\u00a0+\u00a0AMX<\/jats:styled-content> are more effective than mechanical treatment alone in reducing the levels and prevalence of sites colonized by Archaea<\/jats:italic> in subjects with chronic periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/idh.12347","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T00:39:03Z","timestamp":1527122343000},"page":"569-575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of different periodontal treatments in changing the prevalence and levels of Archaea<\/i> present in the subgingival biofilm of subjects with periodontitis: A secondary analysis from a randomized controlled clinical trial"],"prefix":"10.1111","volume":"16","author":[{"given":"FS","family":"Ramiro","sequence":"first","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University Guarulhos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EAG","family":"de Lira","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Research Division Guarulhos University Guarulhos 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