{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:33:11Z","timestamp":1790357591488,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,25]],"date-time":"2018-12-25T00:00:00Z","timestamp":1545696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dental Hygiene"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this randomized, parallel\u2010design, clinical trial was to investigate the effectiveness of an intensive plaque control programme with sonic versus manual toothbrushing on clinical outcomes and gingival crevicular fluid (GCF) levels of matrix metalloproteinases (MMP) in desquamative gingivitis (DG) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 32 patients affected by DG secondary to oral lichen planus (OLP) were consecutively recruited and randomly assigned to a test (n\u00a0=\u00a016) and control (n\u00a0=\u00a016) group. Both groups were enrolled in an intensive control programme comprising supragingival scaling and polishing, and brush\u2010specific instructions for a period of 8\u00a0weeks. The treatment of interest (test) was the use of a sonic\u2010powered toothbrush, and the standard treatment (control) was the utilization of a soft\u2010bristle manual toothbrush for twice\u2010daily home oral hygiene procedures. Periodontal parameters, patient\u2010centred outcomes, MMP\u20101 and MMP\u20109 GCF levels were evaluated at baseline and 8\u00a0weeks after starting the programme.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The plaque control programme resulted in statistically significant reduction in periodontal parameters with consequent improvement in the clinical features, painful symptoms and severity of DG lesions in both groups (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). When a sonic toothbrush was used, there was a more significant decrease in clinical indices, mucosal disease scores and GCF levels of MMP\u20101 and MMP\u20109.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This clinical trial reported the effectiveness of a combined protocol based on professional oral hygiene and supervised toothbrushing in OLP patients with DG. The daily use of a sonic toothbrush would seem to perform better in the short term.<\/jats:p><\/jats:sec>","DOI":"10.1111\/idh.12377","type":"journal-article","created":{"date-parts":[[2018,12,2]],"date-time":"2018-12-02T13:59:36Z","timestamp":1543759176000},"page":"161-169","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effect of sonic versus manual supervised toothbrushing on both clinical and biochemical profiles of patients with desquamative gingivitis associated with oral lichen planus: A randomized controlled trial"],"prefix":"10.1111","volume":"17","author":[{"given":"Laura","family":"Bianco","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences, C.I.R. 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