{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:08:52Z","timestamp":1778620132264,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T00:00:00Z","timestamp":1554163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Colgate-Palmolive Europe s\u00e0rl, Therwil, Switzerland"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dental Hygiene"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This single\u2010centre, controlled, randomized, double\u2010blinded clinical study in parallel groups was performed to assess the efficacy of an experimental toothpaste on plaque and gingivitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In adult subjects with gingivitis, amine fluoride\/stannous chloride toothpaste (test) and monofluorophosphate toothpaste (control) were applied twice daily by regular toothbrushing at home. Evaluations of plaque index (PI), gingival index (GI), modified sulcus bleeding index (mSBI) and safety took place at baseline and after 3 and 12\u00a0weeks of study product use. After study completion, all subjects received a dental prophylaxis. A descriptive statistical analysis included means and standard deviations. Unpaired <jats:italic>t<\/jats:italic> tests compared index reductions between groups at a significance level of 0.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Intention\u2010to\u2010treat analysis included 240 out of 241 subjects. Baseline mean PI was reduced by 0.87\u00a0\u00b1\u00a00.35 in the test group and by 0.65\u00a0\u00b1\u00a00.41 in the control group. Within\u2010group differences and between\u2010group differences in index reduction were statistically significant (<jats:italic>P<\/jats:italic> &lt; 0.001). Mean GI and mSBI were reduced significantly over time (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) with no clinically meaningful differences between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both toothpastes reduced plaque and gingivitis statistically significant and clinically meaningful over 12\u00a0weeks. Compared to the control toothpaste, application of the amine fluoride\/stannous chloride toothpaste led to a clinically meaningful and more pronounced plaque reduction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/idh.12392","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T06:09:51Z","timestamp":1551161391000},"page":"237-243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of toothpaste containing amine fluoride and stannous chloride on the reduction of dental plaque and gingival inflammation. 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