{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:03:03Z","timestamp":1789498983385,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T00:00:00Z","timestamp":1554854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dental Hygiene"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this RCT study was to compare early wound healing and gingival crevicular fluid cytokine levels of patients treated with two different post\u2010surgical cleansing protocols.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 30 chronic periodontitis patients scheduled for osseous resective surgery with fibre retention technique were randomly assigned to follow one of two post\u2010surgical protocols. Patients assigned to the test protocol (n\u00a0=\u00a015) were instructed to brush the surgical area with a sonic toothbrush starting the day after surgery in addition to 0.12% chlorhexidine (CHX) rinsing, while patients following the control protocol (n\u00a0=\u00a015) rinsed only with 0.12% CHX solution and resumed mechanical cleansing with a manual toothbrush on day 14 after surgery. Interleukin (IL)\u20101\u03b2 and IL\u20108 levels were assessed before and 14\u00a0days post\u2010operatively in gingival crevicular fluid. Patients were recalled on day 7, 14, 21 and 28 after surgery for clinical assessment. Pain was self\u2010reported by a visual analogue scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lower early wound healing scores, higher bacterial plaque reduction and milder inflammatory response were observed at the surgical sites in the test group on day 7, 14 and 28 when compared to the control group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). The faster wound healing process was modulated by a statistically significant decrease in IL\u20101\u03b2 and IL\u20108 levels on day 14 in the sonic group. The intensity of pain was similar between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The introduction of sonic toothbrush on the first post\u2010operative day as an adjunct of daily CHX rinsing would seem to accelerate early wound healing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/idh.12395","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T15:22:24Z","timestamp":1553095344000},"page":"300-308","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effect of two post\u2010surgical cleansing protocols on early periodontal wound healing and cytokine levels following osseous resective surgery: A randomized controlled study"],"prefix":"10.1111","volume":"17","author":[{"given":"Ziad","family":"Sijari","sequence":"first","affiliation":[{"name":"Postgraduate Program in Periodontology University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5172-299X","authenticated-orcid":false,"given":"Federica","family":"Romano","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, C.I.R. 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