{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T02:46:14Z","timestamp":1784169974907,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dental Hygiene"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the efficacy of boric acid as an adjunct to non\u2010surgical periodontal therapy, in comparison with a placebo adjunct, in terms of changes in probing pocket depth (PPD) and clinical attachment level (CAL), in patients with periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four electronic databases were searched from inception to May 2020 (PubMed, Cochrane CENTRAL, EMBASE via OVID and Web of Science). Clinical outcomes were extracted, pooled and meta\u2010analyses conducted using mean difference with standard deviations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For PPD, a mean additional reduction of 0.58\u00a0mm (95% CI: \u22120.03\u20131.19\u00a0mm, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.06) was observed at 3\u00a0months and a mean additional reduction of 1.18\u00a0mm (95% CI: 0.97\u20131.40\u00a0mm, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) at 6\u00a0months, compared with placebo.<\/jats:p><jats:p>For CAL, a mean additional gain of 0.62\u00a0mm (95% CI: \u22120.07\u20131.32\u00a0mm, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.08) was observed at 3\u00a0months and a mean additional gain of 1.24\u00a0mm (95% CI: 0.89\u20131.58\u00a0mm, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) at 6\u00a0months, compared with placebo. No adverse events were reported in any studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The adjunctive use of boric acid in non\u2010surgical periodontal therapy results in improved treatment outcomes at 3 and 6\u00a0months, with no adverse events reported.<\/jats:p><\/jats:sec>","DOI":"10.1111\/idh.12487","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T19:30:03Z","timestamp":1611948603000},"page":"139-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Boric acid as an adjunct to periodontal therapy: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7416-7610","authenticated-orcid":false,"given":"Nasir Zeeshan","family":"Bashir","sequence":"first","affiliation":[{"name":"School of Dentistry University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Krstic","sequence":"additional","affiliation":[{"name":"School of Dentistry University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,15]]},"reference":[{"issue":"14","key":"e_1_2_10_2_1","first-page":"216","article-title":"Advances in the pathogenesis of periodontitis: summary of developments, clinical implications and future directions","volume":"1997","author":"Page RC","year":"2000","journal-title":"Periodontol 2000"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1990.61.9.543"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCIDE.S7712"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1996.1.1.443"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2005.00148.x"},{"issue":"9","key":"e_1_2_10_7_1","first-page":"676","article-title":"Host modulation therapeutics in periodontics: role as an adjunctive periodontal therapy","volume":"24","author":"Shinwari MS","year":"2014","journal-title":"J Coll Physicians Surg Pak"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobcr.2019.05.001"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-018-2354-9"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-237X.188572"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/idj.12384"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12427"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1678-77572012000300002"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090285"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12094"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2014.898789"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm050676a"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jicd.12279"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-011-9094-x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01408.x"},{"issue":"3","key":"e_1_2_10_22_1","doi-asserted-by":"crossref","first-page":"457","DOI":"10.4103\/ccd.ccd_752_18","article-title":"Comparative evaluation of boric acid gel versus chlorhexidine gel in the treatment of chronic periodontitis: randomized. 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