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Clinical parameters were recorded, and gingival crevicular fluid (GCF) and subgingival plaque samples were collected at baseline, 3 and 6\u00a0months after treatment. GCF levels of interleukin (IL)\u20101\u03b2 and IL\u201017 were analysed using ELISA. Quantities of six bacterial species were determined using qPCR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Clinical parameters improved significantly in all groups at 3 and 6\u00a0months (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Percentage of sites with probing depth &gt;6\u00a0mm was lower in the FMD than Q\u2010SRP group at 3 and 6\u00a0months (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). FMD showed significantly higher percentage of pocket closure compared with Q\u2010SRP and FM\u2010SRP at both 3 and 6\u00a0months after treatment (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). The IL\u20101\u03b2 levels decreased only in the FMD group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), whereas no changes were found in IL\u201017\u00a0levels in any group. The levels of five out of six bacterial species decreased at 3 and\/or 6\u00a0months only in the FMD group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The FMD treatment appears to offer superior outcome than Q\u2010SRP and could be the first choice for patients with GAgP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/idh.12592","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T17:38:45Z","timestamp":1644514725000},"page":"347-363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Different scaling and root planing strategies in Turkish patients with aggressive periodontitis: A randomized controlled clinical 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