{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T14:33:45Z","timestamp":1793111625837,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dental Hygiene"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Interleukins are the markers of inflammation and the lipid profile reveals the likelihood of arising cardiovascular disease (CVD). The present study aimed to assess and correlate the influence of non\u2010surgical periodontal therapy (NSPT) on serum lipid profile and Interleukin\u20106 (IL\u20106) and Interleukin\u20108 (IL\u20108) in patients with Stage III periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty patients with the age range of 35\u201360\u2009years with Stage III periodontitis were included by evaluating for periodontal parameters such as Probing pocket depth (PPD) and clinical attachment levels (CAL). NSPT was performed at baseline, 3 and 6\u2009months. Biochemical parameters like serum lipid parameters of total cholesterol (TC), triglycerides (TG), low\u2010density lipopolysaccharide (LDL), high\u2010density lipopolysaccharide (HDL), and IL\u20106 and IL\u20108 serum levels were assessed at baseline and 6\u2009months' post\u2010NSPT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The results indicated a significant reduction (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) in the PPD (2.75\u2009\u00b1\u20090.41), CAL (3.23\u2009\u00b1\u20090.56), lipid profile, and serum cytokine levels 6\u2009months' post\u2010NSPT as compared to baseline. A highly significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) percentage reduction was observed in the IL\u20106 (35.3%), IL\u20108 (41.6%), TC (7.5%), TG (1.78%), LDL (6.2%), and HDL (\u221221.8%) clinical and biochemical parameters at 6\u2009months' recall post\u2010NSPT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Non\u2010surgical periodontal therapy caused a significant reduction in the levels of serum pro\u2010inflammatory cytokines IL\u20106 and IL\u20108 as well as the lipid biomarkers TC, TG, LDL, and increase values of HDL. These findings imply a considerable reduction in the risk of developing CVD in patients with Stage III periodontitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/idh.12639","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T06:58:43Z","timestamp":1666853923000},"page":"298-304","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Assessment and correlation of the influence of non\u2010surgical periodontal therapy on serum lipid profile and cytokines in patients with stage\n                    <scp>III<\/scp>\n                    periodontitis"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5735-5908","authenticated-orcid":false,"given":"Abhay Pandurang","family":"Kolte","sequence":"first","affiliation":[{"name":"Department of Periodontics and Implant Dentistry VSPM Dental College and Research Centre  Nagpur 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