{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T01:25:44Z","timestamp":1769045144104,"version":"3.49.0"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dental Hygiene"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Oral cancer is a severe and potentially fatal disease usually starting in the squamous epithelium lining the oral cavity. Together with oropharyngeal carcinoma, it is the fifth to sixth most common malignancy worldwide. To limit the increase in the global oral cancer incidence over the past two decades, the World Health Assembly adopted a resolution urging member states to integrate preventive measures such as engagement and training of dental personnel in screening, early diagnosis, and treatment into their national cancer control programs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to investigate if dental hygienists (DHs) and dentists (Ds) in general dental practice care can be entrusted to perform brush sampling of oral potentially malignant disorders (OPMDs), and to evaluate their level of comfort in performing brush biopsies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants were five DHs and five Ds who received one day of theoretical and clinical training in oral pathology to identify OPMDs (leukoplakia [LP], erythroplakia [EP], and oral lichen planus [OLP]), and perform brush sampling for PAP cytology and high\u2010risk human papillomavirus (hrHPV) analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 222 collected samples, 215 were adequate for morphological assessment and hrHPV analysis. All the participants agreed that sample collection can be incorporated in DHs and Ds routine clinical duties, and most of them reported that sample collection and processing was easy\/quite easy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dentists and DHs are capable of collecting satisfactory material for cytology and hrHPV analysis. All the participating DHs and Ds were of the opinion that brush sampling could be handled routinely by DHs and Ds in GDP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/idh.12713","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T12:11:11Z","timestamp":1688472671000},"page":"524-532","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Dental hygienists and dentists as providers of brush biopsies for oral mucosa screening"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3312-300X","authenticated-orcid":false,"given":"Kristina","family":"Edman","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences, Odontology &amp; Maxillofacial Surgery Uppsala University  Uppsala Sweden"},{"name":"Administrative Center for Public Dental Service  Falun Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina Runow","family":"Stark","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Odontology &amp; Maxillofacial Surgery Uppsala University  Uppsala Sweden"},{"name":"Department of Maxillofacial Surgery and Orofacial Medicine Folktandv\u00e5rden Karlskrona, Region Blekinge  Karlskrona Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Basic","sequence":"additional","affiliation":[{"name":"Pathology and Cytology Region Dalarna  Falun Sweden"},{"name":"Department of Natural Science and Biomedicine, School of Health and Welfare J\u00f6nk\u00f6ping University  J\u00f6nk\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7312-8222","authenticated-orcid":false,"given":"Joakim","family":"Lindblad","sequence":"additional","affiliation":[{"name":"Department of Information Technology Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan\u2010Micha\u00e9l","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Odontology &amp; Maxillofacial Surgery Uppsala University  Uppsala Sweden"},{"name":"Department of Research &amp; Development Folktandv\u00e5rden Stockholm AB, Region Stockholm  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1875-595X.2008.tb00185.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.06.002"},{"key":"e_1_2_11_4_1","unstructured":"Socialstyrelsen.www.socialstyrelsen.se\/statistik\/statistikdatabas;2017."},{"key":"e_1_2_11_5_1","unstructured":"Cancerfonden.Cancerfondsrapporten2018.https:\/\/static\u2010files.cancerfonden.se\/Cancerfondsrapporten2018_webb_(2)_1521607903.pdf"},{"key":"e_1_2_11_6_1","unstructured":"SweHNCR R.c.v.Kvalitetsregisterrapporter huvud\u2010 och halscancer (Swedish head and neck cancer register);2017."},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24994"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22177"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480601110170"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2003.008656"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-012-0377-0"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.6995"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480510012273"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26006"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12143"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2003.00031.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12264"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.2478\/raon-2018-0031"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2000.290707.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.19286"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-020-01351-9"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.12587"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(86)90422-6"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.52.4.195"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12339"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2011.01337.x"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2004.12.003"},{"key":"e_1_2_11_28_1","first-page":"1","article-title":"A prevalence study of oral mucosal lesions in an adult Swedish population","volume":"36","author":"Axell T","year":"1976","journal-title":"Odontol Revy Suppl"},{"key":"e_1_2_11_29_1","unstructured":"Regionala cancercentrum i samverkan.Cervixcancer\u2010prevention (Cervixcancer prevention) [in Swedish];2021[cited 2022 January 31]."},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2010.00910.x"},{"issue":"5","key":"e_1_2_11_31_1","first-page":"706","article-title":"Cytobrush and wooden spatula for oral exfoliative cytology. A comparison","volume":"36","author":"Ogden GR","year":"1992","journal-title":"Acta Cytol"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1155\/2003\/305151"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12660"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12663-022-01710-9"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/idh.12190"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11111813"},{"issue":"1","key":"e_1_2_11_37_1","first-page":"4","article-title":"Application of oral CDx brush biopsy in oral cancer detection","volume":"1","author":"Bhosale S","year":"2019","journal-title":"J Dent Res Prac"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12759"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42979-021-00676-8"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-50516-5_22"},{"key":"e_1_2_11_41_1","unstructured":"KoriakinaN SladojeN BengtssonE et al.Visualization of convolutional neural network class activations in automated oral cancer detection for interpretation of malignancy associated changes in 3rd NEUBIAS Conference;2019: Luxembourg.http:\/\/urn.kb.se\/resolve?urn=urn:nbn:se:uu:diva\u2010398145"},{"key":"e_1_2_11_42_1","unstructured":"Haj\u2010HosseiniN LindbladJ Hass\u00e9usB HirschJM.Kan icke\u2010invasiva tekniker vid kontroll av potentiellt maligna munslemhinnef\u00f6r\u00e4ndringar ers\u00e4tta traditionella v\u00e4vnadsbiopsier (Can non\u2010invasive techniques in the control of potentially malignant mucosal changes replace traditional tissue biopsies?)[in Swedish].Tandl\u00e4kartidningen.2021."},{"key":"e_1_2_11_43_1","unstructured":"BaborT Higgins BiddleJ AundersJ MonteiroM.Audit. The alcohol disorders Identification Test. Guidelines for use in primary care;2001. WHO: AUDIT: the Alcohol Use Disorders Identification Test: guidelines for use in primary health care (who.int). Accessed September 15th 2021."},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/37.3.245"},{"issue":"1","key":"e_1_2_11_45_1","first-page":"37","article-title":"Comparison of two Papanicolaou staining procedures for automated prescreening","volume":"1","author":"Soost HJ","year":"1979","journal-title":"Anal Quant Cytol"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta19220"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1159\/000457827"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.51916.1"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22599"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12208"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12709"},{"key":"e_1_2_11_52_1","unstructured":"Statens beredning f\u00f6r medicinsk och social utv\u00e4rdering.Borstbiopsier vid diagnostik av cancer i munh\u00e5lan (Brush biopsies in the diagnosis of oral cancer)[in Swedish].Dnr: SBU 2021\/418."},{"issue":"645","key":"e_1_2_11_53_1","first-page":"1","article-title":"Cost\u2010effectiveness analysis of repeated self\u2010sampling for HPV testing in primary cervical screening: a randomized study","volume":"20","author":"Aarnio R","year":"2020","journal-title":"BMC Cancer"}],"container-title":["International Journal of Dental Hygiene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/idh.12713","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T02:59:43Z","timestamp":1692327583000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/idh.12713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,4]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/idh.12713"],"URL":"https:\/\/doi.org\/10.1111\/idh.12713","archive":["Portico"],"relation":{},"ISSN":["1601-5029","1601-5037"],"issn-type":[{"value":"1601-5029","type":"print"},{"value":"1601-5037","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,4]]},"assertion":[{"value":"2022-03-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}