{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T10:30:27Z","timestamp":1772361027781,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1C1C1005306"],"award-info":[{"award-number":["2020R1C1C1005306"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dental Hygiene"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study was conducted in order to determine the effect on halitosis and the antibacterial effect against halitosis\u2010causing bacteria of the mouthwash made of the natural material, <jats:italic>Glycyrrhiza uralensis<\/jats:italic> (<jats:italic>G. uralensis<\/jats:italic>) extract.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A randomized, double\u2010blind, placebo\u2010controlled study was conducted on 60 patients who visited M dental clinic located in Busan, South Korea, excluding those with systemic disease that may induce halitosis. There were 30 patients classified to the saline gargle group and the remaining 30 patients were classified to the <jats:italic>G.\u2009uralensis<\/jats:italic> extract gargle group. In addition, their level of halitosis and halitosis\u2010causing bacteria were measured. They visited the dental clinic on a fasted state at baseline before gargle application (Baseline), immediately after gargle application (Treatment) and 5\u2009days after gargle application (After 5\u2009Days). For clinical indicators, participants were tested for halitosis and bacteria immediately after waking up without brushing their teeth and without hydration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of halitosis decreased in the <jats:italic>G.\u2009uralensis<\/jats:italic> extract gargle group compared to the saline gargle group at Treatment and After 5\u2009Days. In cases with pseudo halitosis, there was a significant decrease in halitosis\u2010causing bacteria when <jats:italic>G.\u2009uralensis<\/jats:italic> extract gargle was applied (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It was identified that using a mouthwash made with <jats:italic>G.\u2009uralensis<\/jats:italic> extract is effective for halitosis improvement and reduction of halitosis\u2010causing bacteria. Therefore, using a mouthwash containing <jats:italic>G.\u2009uralensis<\/jats:italic> extract, it will be effective in improving bad breath and oral hygiene will be possible.<\/jats:p><\/jats:sec>","DOI":"10.1111\/idh.12724","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T07:39:55Z","timestamp":1693208395000},"page":"614-625","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of halitosis according to herbal mouthwash containing <i>Glycyrrhiza uralensis<\/i> extract and saline mouthwash: A randomized, double\u2010blind, placebo\u2010controlled study"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6440-6745","authenticated-orcid":false,"given":"Yu\u2010Rin","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dental Hygiene Silla University  Busan South 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