{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T23:38:23Z","timestamp":1773790703155,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T00:00:00Z","timestamp":1695600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dental Hygiene"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In community settings with limited dental personnel and equipment, and in an era when the aerosol transmission of infectious agents is on the rise, a non\u2010invasive approach to caries management is critical. To provide information on non\u2010invasive material selection, the aim of this study was to compare the remineralization effect of commonly used fluoride\u2010containing materials, adjunctive to the everyday use of fluoride toothpaste (F\u2010toothpaste), on primary tooth natural dentin caries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010five specimens were randomly divided into five groups: 38% silver diamine fluoride (SDF), 5% fluoride varnish (F\u2010varnish), glass\u2010ionomer cement (GIC), deionized water (DW) with F\u2010toothpaste slurry, and DW as a control group (<jats:italic>n<\/jats:italic>\u2009=\u200911). The lesion depth and mineral density were measured before and after bacterial pH\u2010cycling using micro\u2010computed tomography. The percentage of mineral density change (%MDchange) was quantified. The dependent <jats:italic>t<\/jats:italic>\u2010test, Wilcoxon\u2010Signed\u2010Rank Test, and one way ANOVA with Bonferroni correction were used to analyse the data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SDF application reduced lesion depth from 844.6 to 759.1\u2009\u03bcm (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.045) while increasing mineral density from 551.4 to 763.0\u2009mgHA\/cm<jats:sup>3<\/jats:sup> (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.003). Only mineral density rose from 600.2 to 678.4\u2009mgHA\/cm<jats:sup>3<\/jats:sup> (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.013) when GIC was used. The other groups showed no difference. The highest %MDchange was also found after SDF treatment (49.7%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), whereas GIC (17.2%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) presented a higher percentage than the F\u2010varnish (2.0%), F\u2010toothpaste (\u22121.1%) and no\u2010treatment groups (\u22121.4%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this in vitro study, where the pH of cycling was almost neutral, using SDF as an adjunct to F\u2010toothpaste resulted in the highest remineralization compared with other remineralizing materials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/idh.12765","type":"journal-article","created":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T09:40:36Z","timestamp":1695634836000},"page":"689-695","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Material of choice for non\u2010invasive treatment of dentin caries: An in vitro study using natural carious lesions"],"prefix":"10.1111","volume":"22","author":[{"given":"Maneekarn","family":"Kongsomjit","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kulnipa","family":"Punyanirun","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wacharaporn","family":"Tasachan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenori","family":"Hamba","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry, Cariology and Pulp Biology Tokyo Dental College  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junji","family":"Tagami","sequence":"additional","affiliation":[{"name":"Department of Cariology and Operative Dentistry, Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo Japan"},{"name":"Department of Operative Dentistry Faculty of Dentistry, Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chutima","family":"Trairatvorakul","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1378-695X","authenticated-orcid":false,"given":"Panida","family":"Thanyasrisung","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Center of Excellence on Oral Microbiology and Immunology, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002278"},{"key":"e_1_2_11_3_1","volume-title":"Fluoride Therapy","author":"American Academy of Pediatric Dentistry","year":"2020"},{"key":"e_1_2_11_4_1","unstructured":"FDI World Dental Federation.Oral Health Worldwide. A report by FDI World Dental Federation. Accessed August 8 2020.https:\/\/www.fdiworlddental.org\/sites\/default\/files\/2020\u201011\/2015_wohd\u2010whitepaper\u2010oral_health_worldwide.pdf"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphd.12259"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40368-020-00547-5"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/dj7010028"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000485983"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2012.08.002"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2015.05.006"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000504335"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0206296"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-0707.136338"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/1807-2577.08815"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000260692"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000480522"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0103-64402008000100004"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.2013.47"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000262146"},{"issue":"3","key":"e_1_2_11_20_1","first-page":"176","article-title":"Effects of four anticaries agents on lesion depth progression in an in vitro caries model","volume":"21","author":"Klein U","year":"1999","journal-title":"Pediatr Dent"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-005-0271-9"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343573"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2009.01127.x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/002203459207100S27"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000261028"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/s19040874"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-38137-7"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-018-0686-0"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.4103\/1735-3327.201137"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10005-1210"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345010800120901"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2017.09.005"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-015-1603-4"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345211026838"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/idj.12320"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10005-1885"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2008.10.014"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.17796\/jcpd.34.3.ut5444720r61375h"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijos.2015.55"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345950740060501"},{"issue":"2","key":"e_1_2_11_41_1","first-page":"119","article-title":"Fluoride varnish concentration gradient and its effect on enamel demineralization","volume":"25","author":"Hazelrigg CO","year":"2003","journal-title":"Pediatr Dent"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.57.177"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1177\/0810767"},{"issue":"3","key":"e_1_2_11_44_1","first-page":"140","article-title":"Micromorphological evaluation of dentin treated with different desensitizing agents","volume":"4","author":"Osmari D","year":"2013","journal-title":"J Lasers Med Sci"},{"issue":"6","key":"e_1_2_11_45_1","first-page":"1503","article-title":"Effect of fluoride varnishes containing different calcium phosphate sources on mineralization of initial primary enamel lesions","volume":"45","author":"Rirattanapong P","year":"2014","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-5037.2003.00001.x"}],"container-title":["International Journal of Dental Hygiene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/idh.12765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T08:25:49Z","timestamp":1721636749000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/idh.12765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,25]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/idh.12765"],"URL":"https:\/\/doi.org\/10.1111\/idh.12765","archive":["Portico"],"relation":{},"ISSN":["1601-5029","1601-5037"],"issn-type":[{"value":"1601-5029","type":"print"},{"value":"1601-5037","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,25]]},"assertion":[{"value":"2022-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}